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<p>α-Cyanoacrylate medical adhesive is one of the materials that can achieve rapid hemostasis. However, its traditional delivery methods have many problems in practical operation. In this study, the α-ethyl cyanoacrylate (ECA) plasticized by biodegradable material polycaprolactone was used as precursor, and a comparative study was conducted on the delivery of ECA using two promising methods of electrostatic spinning technology (EST) and electrostatic spray deposition (ESD). Micromorphology analyses showed that the surface of the film obtained by ESD on aluminum foil exhibited relatively uniform characteristics compared with EST. The particle size distribution by ESD was more uniform than that of EST under the same working parameters. The peel strength and tensile strength of ESD film were 39.2% and 13.6%, respectively, higher than those of EST film, and ESD film folded 90° repeatedly up to 600 times without breaking. What’s more, the use of ESD could improve the wettability of ECA film, which would be conducive to film biodegradation. Biological surface coating experiment exhibited that ESD film could complete and continuous attachment to the surface of fresh pig liver with a good sealing effect. The results indicated that ESD had more prominent efficiency and adaptability for CA medical hemostasis in the medical field.</p>

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A Prospective Technology: Hemostasis with α-Cyanoacrylate Medical Adhesive via Electrostatic Spray Deposition Mode

  • 期刊论文

  • 发表日期：

    2025年3月30日

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  • Lei Wang,
  • Yujie Cao,
  • Luxuan Ma,
  • Wenqing An,
  • Dong Chen,
  • Kai Xia,
  • Kai Jiang,
  • Zhaojun Chen

摘要

α-Cyanoacrylate medical adhesive is one of the materials that can achieve rapid hemostasis. However, its traditional delivery methods have many problems in practical operation. In this study, the α-ethyl cyanoacrylate (ECA) plasticized by biodegradable material polycaprolactone was used as precursor, and a comparative study was conducted on the delivery of ECA using two promising methods of electrostatic spinning technology (EST) and electrostatic spray deposition (ESD). Micromorphology analyses showed that the surface of the film obtained by ESD on aluminum foil exhibited relatively uniform characteristics compared with EST. The particle size distribution by ESD was more uniform than that of EST under the same working parameters. The peel strength and tensile strength of ESD film were 39.2% and 13.6%, respectively, higher than those of EST film, and ESD film folded 90° repeatedly up to 600 times without breaking. What’s more, the use of ESD could improve the wettability of ECA film, which would be conducive to film biodegradation. Biological surface coating experiment exhibited that ESD film could complete and continuous attachment to the surface of fresh pig liver with a good sealing effect. The results indicated that ESD had more prominent efficiency and adaptability for CA medical hemostasis in the medical field.