Let H and K be separable infinite-dimensional Hilbert spaces, and let \(A\in B(H)\) and \(B\in B(K)\) be given operators. We denote by \(M_C\) the operator acting on \(H\oplus K\) of the form \(M_C=\left( \begin{array}{cc}A&{}C\\ 0&{}B\\ \end{array}\right) \) . In this paper, some necessary and sufficient conditions are obtained for \(M_C\) to be a Fredholm operator with \(n(M_C)>0\) and \(\hbox {ind}(M_C)<0\) for some left invertible or invertible operator \(C\in B(K,H)\) . Meanwhile, for the nullity of \(M_C\) , we discuss the relationship between \(n(M_C)\) and n(A) by different method. As the application of above results, the weak properties of Weyl’s theorem for upper triangular operator matrices are explored.