We investigate in this paper the Cauchy problem of the one-dimensional wave equation with space-dependent damping of the form \(\mu _0(1+x^2)^{-1/2}\) , where \(\mu _0>0\) , and time derivative nonlinearity. We establish global existence of mild solutions for small-data compactly supported by employing energy estimates within suitable Sobolev spaces of the associated homogeneous problem. Furthermore, we derive a blow-up result under some positive initial data by employing the test function method. This shows that the critical exponent is given by \(p_G(1+\mu _0)=1+2/\mu _0\) , when \(\mu _0\in (0,1]\) , where \(p_G\) is the Glassey exponent. To the best of our knowledge, this constitutes the first identification of the critical exponent range for this class of equations. As by product, we extend the global existence result to a more general class of space/time nonlinearities of the form \(f(\partial _tu,\partial _x u)=|\partial _x u|^{q}\) or \(f(\partial _tu,\partial _x u)=|\partial _tu|^{p}|\partial _x u|^{q}\) , with \(p,q>1\) .