In this work, we consider the Hénon- Kirchhoff–Boussinesq type problem \(\begin{aligned} \Delta ^2 u \pm \operatorname {div} \big (|x|^{\kappa } | \nabla u |^{p-2} \nabla u \big ) = |x|^\ell f(u) {\text { in }} B,\qquad u = \frac{\partial u}{\partial \nu } = 0 {\text { on }} \partial B, \end{aligned}\) where \(B\subset \mathbb {R}^{N}\) , \(N \ge 5\) , is the unit ball, \(\ell >0\) , \(2<p<2(N+\kappa )/(N-2)\) and \(f(u) \sim |u|^{q-2}u\) , with \(2<q<2(N+\ell )/(N-4)\) . By using Variational Methods, we obtain the existence and multiplicity of weak solution when \(\kappa >0\) is small. Note that f may grow faster than the critical exponent \(2N/(N-4)\) for the Sobolev embedding of \(H^2(B)\) .