In this paper, we study the fractional Schrödinger equation with potentials: \(\begin{aligned} (-\Delta )^{s}u=\lambda u+P(x)|u|^{p-2}u+Q(x)|u|^{q-2}u, \quad \text{ in }\,\,{\mathbb {R}}^{N},\,\,N> 2s, \end{aligned}\) having prescribed mass \(\begin{aligned} \int _{{\mathbb {R}}^{N}}|u|^{2}dx=a, \,\,\text {with}\,\, a>0, \end{aligned}\) where \(s\in (0,1)\) , \(\lambda \in {\mathbb {R}}\) is unknown and appears as a Lagrange multiplier and \(2\le p<q<2^{*}_{s}=\frac{2N}{N-2s}\) is the fractional critical Sobolev exponent. Under certain assumptions on the potentials P(x) and Q(x), we prove several existence results, by recovering the compactness for a minimizing sequence on a suitable manifold and comparing the essential influences due to the nonconstant potentials.