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<p>High-molecular-weight disinfection byproducts (HMW DBPs) have been increasingly recognized as contaminants that pose potential hazards to human health. However, reliable analytical methods for exploring the properties and structures of these DBPs remain limited. This study presents a novel approach for detecting and identifying HMW DBPs via matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The experimental conditions were optimized by selecting super-2,5-dihydroxybenzoic acid (super-DHB) as the matrix and sodium trifluoroacetate as the cationization agent and employing the sandwich deposition method in reflection-positive ion mode with 90% laser intensity, resulting in the highest peak intensity for HMW DBPs. These optimized conditions enhanced peak reproducibility, yielding a signal-to-noise ratio of 134.9 and a coefficient of variation of 3.8%. With the new approach, five HMW DBPs were detected in simulated drinking water and identified as oligosaccharide carboxylic acids via isotopic pattern analysis, tandem mass spectrometry analysis in laser-induced dissociation mode, and database verification.</p>

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High-molecular-weight disinfection byproducts in simulated drinking water: characterization and identification via matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

  • 期刊论文

  • 发表日期：

    2025年5月30日

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  • Zi-Ang Zhang,
  • Liangliang Han,
  • Guang Huang,
  • Peng Shi,
  • Qing Zhou,
  • Jingfan Qiu,
  • Yang Pan

摘要

High-molecular-weight disinfection byproducts (HMW DBPs) have been increasingly recognized as contaminants that pose potential hazards to human health. However, reliable analytical methods for exploring the properties and structures of these DBPs remain limited. This study presents a novel approach for detecting and identifying HMW DBPs via matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The experimental conditions were optimized by selecting super-2,5-dihydroxybenzoic acid (super-DHB) as the matrix and sodium trifluoroacetate as the cationization agent and employing the sandwich deposition method in reflection-positive ion mode with 90% laser intensity, resulting in the highest peak intensity for HMW DBPs. These optimized conditions enhanced peak reproducibility, yielding a signal-to-noise ratio of 134.9 and a coefficient of variation of 3.8%. With the new approach, five HMW DBPs were detected in simulated drinking water and identified as oligosaccharide carboxylic acids via isotopic pattern analysis, tandem mass spectrometry analysis in laser-induced dissociation mode, and database verification.