Purpose <p>To assess whether a virtual, cancer survivorship-focused continuing medical education (CME) course affected awareness of cancer survivorship care and examined barriers to implementing practice changes.</p> Methods <p>We surveyed medical professionals caring for patients and survivors of cancer before, during, and after online course participation from 2021 to 2024. Pre- and post-course test scores across four modules addressing care for patients with various cancer types, cancer and treatment effects, and survivors’ psychosocial and general health were analyzed using paired samples <i>t</i>-tests to determine participant knowledge. Post-course evaluations were analyzed using descriptive statistics and Fisher’s exact tests to measure perceived barriers in implementing practice changes.</p> Results <p>Three hundred fifty-seven medical professionals registered for the CME course; 193 (54.1%) completed all modules (21 CME hours). Most were physicians (42.9%) or nurses (30.8%), 65.3% from the United States. Across all topics, post-course test median scores were significantly higher than median pre-course test scores with 94% course satisfaction. Among 198 who completed the post-course evaluation, 86.9% reported ≧1 barrier to practice change implementation: lack of provider time (34.3%), institutional (30.8%) or insurance/financial barriers (28.3%), and/or challenges in care team members’ communication and/or collaboration (23.7%). Implementing new skills (83.3%), seeking more information (47.0%), and creating/revising practice policies (45.5%) were the most endorsed goals post-CME.</p> Conclusions <p>This CME course presented awareness across cancer survivorship topics; however, multiple barriers exist to clinical practice implementation. Future CMEs should include guidance on overcoming barriers within institutional clinical settings.</p> Implications for cancer survivors <p>An online CME course could strengthen providers’ knowledge of survivorship care.</p>