Purpose <p>People impacted by cancer face increasing challenges in navigating a landscape of abundant health information and misinformation. This study outlines the development and pilot testing of the Informed Health Choices-Cancer (IHC-C) learning resource, designed to provide users the skills and knowledge necessary to think critically about the reliability of health claims and make well-informed choices. This study outlines the development and pilot testing of this learning resource.</p> Methods <p>Using a human-centred design approach, the resource was co-developed with those impacted by cancer through iterative refinement. Tailored content and multimedia formats were used to support over three stages of pilot testing: initial prototype development, testing with small stakeholder groups, and testing with a broader sample. Quantitative ratings and qualitative feedback guided improvements in accessibility, usability, and relevance.</p> Results <p>Thirty-three participants responded positively to the resource, noting its accessible language, practical content, and engaging format. In the final round of testing, over 80% found the resource as ‘very well aligned’ with learning outcomes, ‘very easy to understand’, ‘very relevant’ to cancer, and ‘very easy to navigate’. Navigation ratings improved from 50.0% at prototype stage to 85.4% at final stage. The resource was perceived as effective in supporting critical thinking, informed decision-making, and reflecting real-life cancer experiences.</p> Conclusions <p>The IHC-C learning resource offers an innovative, practical tool for integrating critical thinking into cancer care. It shows promise in supporting informed decision-making and reduces vulnerability to misinformation.</p> Implications for Cancer Survivors <p>The resource may enhance health literacy and empower survivors to critically evaluate health information and manage their care more confidently.</p>