Purpose <p>This study aimed to understand the positive and negative long-term impact of cancer and its treatment on survivors more than two years post-diagnosis.</p> Methods <p>The Dutch Federation of Cancer Patient Organisations (NFK), with input from patient representatives and researchers, created a national online survey. It was distributed via email, websites, and social media to patient organization members, with additional promotion by partner organizations. Participants shared their experiences regarding the physical and psychological effects of cancer on daily life.</p> Results <p>A total of 5,710 cancer survivors participated. Of these, 73% felt proud of how they coped, 66% reported that cancer reshaped their priorities, 44% saw new opportunities, and 35% enjoyed life more. However, 58% could not be worry-free, and 49% struggled to resume life. Long-term symptoms were common: 55% experienced both physical and psychological symptoms, 33% reported only physical symptoms, and 2% only psychological. The most frequent physical symptoms included fatigue (56%), reduced fitness (47%), neuropathy (32%), sexual issues (25%), and sleep disturbances (24%). Common psychological symptoms were memory/concentration issues (32%), acceptance struggles (19%), depressive feelings (19%), planning issues (18%), and anxiety (16%).</p> Conclusion <p>Cancer survivors often face persistent physical and psychological symptoms, with cancer continuing to affect their lives significantly.</p> Implications for cancer survivors <p>Greater awareness of these long-term consequences among healthcare providers and patients is essential.</p>