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Purpose <p>The number of gastrointestinal (GI) cancer survivors has increased substantially due to improvements in early detection and treatment, yet long-term functional patient outcomes remain poorly characterized. We sought to quantify the burden of activity limitations (AL) and functional limitations (FL) among GI cancer survivors compared with non-GI cancer survivors and the general U.S. population, as well as identify key predictors of cancer-related limitations.</p> Methods <p>The National Health Interview Survey (NHIS), a nationally representative dataset (1997–2023), was queried to examine the prevalence and trends of cancer-related limitations among GI cancer survivors, non-GI cancer survivors, and the general U.S. population. Multivariable logistic regression analyses identified independent predictors of AL and FL, adjusting for demographic and socioeconomic variables.</p> Results <p>Among 5,513 GI cancer and 39,887 non-GI cancer survivors, 50.2% (Relative Risk [RR]: 1.23, 95% CI: 1.19–1.27) and 70.7% (RR: 1.07, 95% CI: 1.05–1.09) of GI cancer survivors reported AL and FL, respectively, compared with non-GI cancer survivors. The general U.S. population had a markedly lower prevalence of AL (13.5%; RR: 0.33, 95% CI: 0.33–0.34) and FL (35.7%; RR: 0.54, 95% CI: 0.53–0.54). GI cancer survivors were older (mean age: 69.1 vs. 65.3 vs. 36.1&#xa0;years), more often single (8.8% vs. 8.6% vs. 28.3%), and more frequently received public insurance (75.1% vs. 68.9% vs. 27.4%) compared with non-GI cancer survivors and the general population (<i>p</i> &lt; 0.05). In multivariable analysis, GI cancer survivors had 21% higher odds of AL (OR: 1.21, 95% CI: 1.11–1.32, <i>p</i> &lt; 0.001) and 11% higher odds of FL (OR: 1.11, 95% CI: 1.00–1.19, <i>p</i> = 0.049).</p> Conclusions <p>GI cancer survivors face a significantly higher burden of functional limitations, influenced by demographic and socioeconomic factors.</p> Implications for Cancer Survivors <p>Addressing functional disparities through targeted rehabilitation and support services may improve long-term outcomes.</p>

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Prevalence and trends of cancer-related daily life limitations among gastrointestinal cancer survivors

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月24日

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  • Azza Sarfraz,
  • Abdullah Altaf,
  • Mujtaba Khalil,
  • Zayed Rashid,
  • Shahzaib Zindani,
  • Areesh Mevawalla,
  • Timothy M. Pawlik

摘要

Purpose

The number of gastrointestinal (GI) cancer survivors has increased substantially due to improvements in early detection and treatment, yet long-term functional patient outcomes remain poorly characterized. We sought to quantify the burden of activity limitations (AL) and functional limitations (FL) among GI cancer survivors compared with non-GI cancer survivors and the general U.S. population, as well as identify key predictors of cancer-related limitations.

Methods

The National Health Interview Survey (NHIS), a nationally representative dataset (1997–2023), was queried to examine the prevalence and trends of cancer-related limitations among GI cancer survivors, non-GI cancer survivors, and the general U.S. population. Multivariable logistic regression analyses identified independent predictors of AL and FL, adjusting for demographic and socioeconomic variables.

Results

Among 5,513 GI cancer and 39,887 non-GI cancer survivors, 50.2% (Relative Risk [RR]: 1.23, 95% CI: 1.19–1.27) and 70.7% (RR: 1.07, 95% CI: 1.05–1.09) of GI cancer survivors reported AL and FL, respectively, compared with non-GI cancer survivors. The general U.S. population had a markedly lower prevalence of AL (13.5%; RR: 0.33, 95% CI: 0.33–0.34) and FL (35.7%; RR: 0.54, 95% CI: 0.53–0.54). GI cancer survivors were older (mean age: 69.1 vs. 65.3 vs. 36.1 years), more often single (8.8% vs. 8.6% vs. 28.3%), and more frequently received public insurance (75.1% vs. 68.9% vs. 27.4%) compared with non-GI cancer survivors and the general population (p < 0.05). In multivariable analysis, GI cancer survivors had 21% higher odds of AL (OR: 1.21, 95% CI: 1.11–1.32, p < 0.001) and 11% higher odds of FL (OR: 1.11, 95% CI: 1.00–1.19, p = 0.049).

Conclusions

GI cancer survivors face a significantly higher burden of functional limitations, influenced by demographic and socioeconomic factors.

Implications for Cancer Survivors

Addressing functional disparities through targeted rehabilitation and support services may improve long-term outcomes.