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Background and Purpose <p>Allostatic load (AL) significantly impacts patient outcomes. This study aimed to explore the association between AL levels and time to deterioration (TTD) of health-related quality of life (HRQoL) in non-small cell lung cancer (NSCLC) patients.</p> Methods <p>A prospective study (May 2017–September 2022) included 362 NSCLC patients from The First Affiliated Hospital of Fujian Medical University. HRQoL was assessed using EORTC QLQ-C30 and EORTC QLQ-LC13 questionnaires, and AL-related biomarkers were collected. Univariate and multivariate Cox regression analyses evaluated the impact of AL on HRQoL TTD.</p> Results <p>TTD events were most common in global health status (QL), physical functioning (PF), and dyspnea (LC-DY). Lower AL levels delayed TTD in emotional functioning (EF) (HR = 2.041, <i>95% CI:</i> 1.404–2.969, <i>P</i> &lt; 0.001), cognitive functioning (CF) (HR = 1.613, <i>95% CI:</i> 1.082–2.403,<i> P</i> = 0.019), insomnia (SL) (HR = 1.553, <i>95% CI:</i> 1.064–2.266, <i>P</i> = 0.022), constipation (CO) (HR = 2.114, <i>95% CI</i>: 1.179–3.791, <i>P</i> = 0.012), and hemoptysis (LC-HA) (HR = 2.316, <i>95% CI</i>: 1.037–5.172, <i>P</i> = 0.041). Multivariate analysis confirmed these findings, except for insomnia, which lost significance.</p> Conclusions <p>Lower AL levels delayed TTD in EF, CF, CO, and LC-HA, highlighting AL’s role in preserving HRQoL in NSCLC patients.</p> Implications for Cancer Survivors <p>HRQoL is critical for cancer survivors. This study underscores the importance of AL to improve HRQoL outcomes in NSCLC patients.</p>

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The relationship between allostatic load levels and time to deterioration of health-related quality of life in non-small cell lung cancer patients

  • 期刊论文

  • 发表日期：

    2025年7月30日

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  • Xi Chen,
  • Jinman Zhuang,
  • Zishan Chen,
  • Shiwen liu,
  • Yuan Xu,
  • Chunting Chen,
  • Jie Yi,
  • Fanglin Yu,
  • Baosong Xie,
  • Fei He

摘要

Background and Purpose

Allostatic load (AL) significantly impacts patient outcomes. This study aimed to explore the association between AL levels and time to deterioration (TTD) of health-related quality of life (HRQoL) in non-small cell lung cancer (NSCLC) patients.

Methods

A prospective study (May 2017–September 2022) included 362 NSCLC patients from The First Affiliated Hospital of Fujian Medical University. HRQoL was assessed using EORTC QLQ-C30 and EORTC QLQ-LC13 questionnaires, and AL-related biomarkers were collected. Univariate and multivariate Cox regression analyses evaluated the impact of AL on HRQoL TTD.

Results

TTD events were most common in global health status (QL), physical functioning (PF), and dyspnea (LC-DY). Lower AL levels delayed TTD in emotional functioning (EF) (HR = 2.041, 95% CI: 1.404–2.969, P < 0.001), cognitive functioning (CF) (HR = 1.613, 95% CI: 1.082–2.403, P = 0.019), insomnia (SL) (HR = 1.553, 95% CI: 1.064–2.266, P = 0.022), constipation (CO) (HR = 2.114, 95% CI: 1.179–3.791, P = 0.012), and hemoptysis (LC-HA) (HR = 2.316, 95% CI: 1.037–5.172, P = 0.041). Multivariate analysis confirmed these findings, except for insomnia, which lost significance.

Conclusions

Lower AL levels delayed TTD in EF, CF, CO, and LC-HA, highlighting AL’s role in preserving HRQoL in NSCLC patients.

Implications for Cancer Survivors

HRQoL is critical for cancer survivors. This study underscores the importance of AL to improve HRQoL outcomes in NSCLC patients.