Purpose <p>Perceived cancer-related cognitive impairment (CRCI) has been reported in prostate cancer survivors. Little is known about how CRCI impacts occupational functioning in working-aged prostate cancer survivors (PCS). This study aimed to investigate the association between CRCI and occupational functioning in PCS.</p> Methods <p>Data from 51 PCS, who were employed at the time of diagnosis, undergoing hormonal treatments (e.g., androgen deprivation therapy) or ‘watchful waiting’/ ‘active surveillance’, were analysed. An online survey assessed CRCI using the FACT-Cog Perceived Cognitive Impairments (PCI20) subscale, the EORTC-QLQ-30 two-item cognitive functioning scale, and a single ‘Yes/No’ CRCI item (i.e., were ‘changes in thinking (e.g., memory, attention)’ experienced as a treatment side effect). PCS also indicated ‘Yes/No’ to changes to their ability to work, performance of work duties, and decreased work hours. Logistic regression analyses examined the relationship between CRCI measures and occupational outcomes.</p> Results <p>Of the 51 PCS, 19 (37%) endorsed experiencing cognitive side effects from treatment. The single ‘Yes/No’ CRCI question was significantly associated with perceived changes in work ability and ability to perform work duties at the same level. PCI20 and the EORTC-QLQ-30 cognitive functioning scale were not significantly associated with any occupational outcomes.</p> Conclusion <p>Perceived CRCI is associated with adverse changes to occupational functioning and is important to consider when PCS are making plans to return-to-work following treatment.</p> Implications for Cancer Survivors <p>Prostate cancer survivors may experience cognitive changes, which may impact their work ability.</p>