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<p>This study compared the protective effects of glutathione (GSH) and liposomal GSH (L-GSH) against -induced oxidative stress with hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) in <i>Saccharomyces cerevisiae</i>. GSH and L-GSH were tested at different concentrations under stressed and non-stressed conditions. The measured parameters were cell growth, intracellular GSH, superoxide dismutase, catalase, and residual H₂O₂. In most of the tested conditions, L-GSH gave better responses, particularly during the early growth period and oxidative stress. Compared with GSH, the liposomal preparation was associated with improved growth and a more favourable pattern of antioxidant-related measurements. Taken together, these results indicate that liposomal encapsulation improved the practical antioxidant effect of GSH in this yeast model.</p>

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Comparative effect of liposomal and free glutathione on Saccharomyces cerevisiae resistance to hydrogen peroxide

  • 期刊论文

  • 发表日期：

    2026年6月23日

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  • Jwan N. Abood,
  • Noor Essam Abdul-Razzaq,
  • Abdul-hameed Mohamed Hamoodi Al-samaraiy,
  • Wael Mohammed Mahdi,
  • Afrah Abdullah Jassim

摘要

This study compared the protective effects of glutathione (GSH) and liposomal GSH (L-GSH) against -induced oxidative stress with hydrogen peroxide (H2O2) in Saccharomyces cerevisiae. GSH and L-GSH were tested at different concentrations under stressed and non-stressed conditions. The measured parameters were cell growth, intracellular GSH, superoxide dismutase, catalase, and residual H₂O₂. In most of the tested conditions, L-GSH gave better responses, particularly during the early growth period and oxidative stress. Compared with GSH, the liposomal preparation was associated with improved growth and a more favourable pattern of antioxidant-related measurements. Taken together, these results indicate that liposomal encapsulation improved the practical antioxidant effect of GSH in this yeast model.