Scholarlink

<p><i>Streptococcus agalactiae</i>, also called Group B <i>Streptococcus</i> (GBS), is a major cause of several infectious diseases in humans and fish. However, the likelihood of GBS transmission between different host species leading to a potential zoonotic problem is less well studied. Understanding the proteomics of GBS is crucial for elucidating its zoonotic potential and developing effective diagnostic and prevention strategies. This study utilized comparative proteomic analysis using LC–MS/MS technique to investigate the similarities and differences between GBS isolates from human and fish sources. The core proteome was found to be highly conserved, with 82.5% of the 1405 identified proteins shared between the two groups. Functional categorization using the Cluster of Orthologous Genes (COG) database revealed that the majority of the proteins were involved in various metabolic pathways, reflecting the diverse catabolic capabilities of GBS. Notably, specific proteins were exclusively expressed in human or fish isolates, suggesting distinct functional roles and adaptation strategies. These findings highlight the importance of comparative proteomic studies in understanding the zoonotic potential and pathogenicity of GBS. The insights gained from this research could inform future risk assessment, diagnostic development and prevention strategies targeting this opportunistic pathogen.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Proteomic typing of invasive group B Streptococcus isolated from humans and fish (Oreochromis spp.; Pisces) in Malaysia

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年6月25日

查看全文
  • AbdulRahman Muthanna,
  • Mohd Nasir Mohd Desa,
  • Mohd Hafis Yuswan,
  • Nurshahira Sulaiman,
  • Nurul Hana Zainal Baharin,
  • Nurul Diana Dzaraly,
  • Mohammad Noor Amal Azmai,
  • Roshariza Haris,
  • Syafinaz Amin-Nordin

摘要

Streptococcus agalactiae, also called Group B Streptococcus (GBS), is a major cause of several infectious diseases in humans and fish. However, the likelihood of GBS transmission between different host species leading to a potential zoonotic problem is less well studied. Understanding the proteomics of GBS is crucial for elucidating its zoonotic potential and developing effective diagnostic and prevention strategies. This study utilized comparative proteomic analysis using LC–MS/MS technique to investigate the similarities and differences between GBS isolates from human and fish sources. The core proteome was found to be highly conserved, with 82.5% of the 1405 identified proteins shared between the two groups. Functional categorization using the Cluster of Orthologous Genes (COG) database revealed that the majority of the proteins were involved in various metabolic pathways, reflecting the diverse catabolic capabilities of GBS. Notably, specific proteins were exclusively expressed in human or fish isolates, suggesting distinct functional roles and adaptation strategies. These findings highlight the importance of comparative proteomic studies in understanding the zoonotic potential and pathogenicity of GBS. The insights gained from this research could inform future risk assessment, diagnostic development and prevention strategies targeting this opportunistic pathogen.