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<p><i>Staphylococcus aureus (S. aureus</i>) is a deadly, gram-positive bacterium causing life-threatening diseases such as fatal pneumonia, sepsis, and severe skin infections highlighting the need for urgent medical intervention. Metal–organic frameworks (MOFs), a novel class of porous materials have recently shown promising antibacterial action against various pathogens possibly due to the slow release of metal ions when dissolved in aqueous media. The current work focuses on exploring the antibacterial potential of Fe-MOF against <i>S. aureus</i>. The assay results substantiate the antibacterial action of Fe BDC MOF in an aqueous environment against <i>S. aureus</i>. Furthermore, a combination of Fe BDC MOF and antibiotic gentamicin exhibits a remarkable enhancement in antimicrobial efficacy with a 34&#xa0;mm zone of inhibition in antibacterial action, demonstrating a synergistic effect between the two compounds against the pathogen. This work paves the way for the development of novel combination drug therapies against <i>S. aureus</i> and other deadly pathogens. To further advance the antibacterial research this study adopts a combination drug therapy approach, screening Fe BDC MOF with gentamicin to combat the growth of <i>S. aureus</i>.</p> Graphical Abstract <p></p>

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Gentamicin-loaded Fe-MOF: A novel strategy for enhanced antibacterial action against Staphylococcus aureus

  • 期刊论文

  • 发表日期：

    2025年5月26日

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  • Prachi Prachi,
  • Archana Archana,
  • Megha Prajapati,
  • Soumya Rai,
  • Pratima R. Solanki,
  • Chhaya Ravi Kant

摘要

Staphylococcus aureus (S. aureus) is a deadly, gram-positive bacterium causing life-threatening diseases such as fatal pneumonia, sepsis, and severe skin infections highlighting the need for urgent medical intervention. Metal–organic frameworks (MOFs), a novel class of porous materials have recently shown promising antibacterial action against various pathogens possibly due to the slow release of metal ions when dissolved in aqueous media. The current work focuses on exploring the antibacterial potential of Fe-MOF against S. aureus. The assay results substantiate the antibacterial action of Fe BDC MOF in an aqueous environment against S. aureus. Furthermore, a combination of Fe BDC MOF and antibiotic gentamicin exhibits a remarkable enhancement in antimicrobial efficacy with a 34 mm zone of inhibition in antibacterial action, demonstrating a synergistic effect between the two compounds against the pathogen. This work paves the way for the development of novel combination drug therapies against S. aureus and other deadly pathogens. To further advance the antibacterial research this study adopts a combination drug therapy approach, screening Fe BDC MOF with gentamicin to combat the growth of S. aureus.

Graphical Abstract