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<p>Different secondary metabolites take on important roles. They can also transport metals, function as sexual hormones, facilitate harmonious coexistence of microbes and living beings, and induce differentiation, besides being used as competitive weapons against other bacteria, fungi, amoebae, plants, insects, and large animals. Progress in next-generation sequencing methods, together with microbial genome sequencing, has unveiled a wealth of natural products (NPs) with yet-untapped potential. Genome mining of <i>Corallococcus</i> species and the subspecies <i>C. exiguus</i>, known for their potential to produce clinically important secondary metabolites, has not been extensively studied. The goal of this study is to look into <i>Corallococcus</i> genomes’ biosynthetic gene clusters (BGCs) and carbohydrate-active enzyme gene clusters. We fully characterize BGCs from <i>Corallococcus</i> reference genome sequences that are publicly available using bioinformatic tools in addition to phylogenetic and genomic comparisons. Our results show that there is a huge range of BGCs in different <i>Corallococcus</i> genomes, but the species or subspecies level affects the ability to make NPs. Additionally, we investigated unknown and less comparable BGCs at the species level and found that <i>C. llansteffanensis</i> has more potential as a reservoir of new secondary metabolites. These insights will pave the way for the algorithmic identification of species- and subspecies-specific pathways for NP development.</p>

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Exploration of the metabolic potential of the Corallococcus genus: a rich source of secondary metabolites and CAZymes

  • 期刊论文

  • 发表日期：

    2025年1月21日

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  • Md. Saddam Hossain,
  • Shanjana Rahman Tuli,
  • Nigar Fatima,
  • Md. Tauhidul Islam Tanim,
  • Abu Hashem

摘要

Different secondary metabolites take on important roles. They can also transport metals, function as sexual hormones, facilitate harmonious coexistence of microbes and living beings, and induce differentiation, besides being used as competitive weapons against other bacteria, fungi, amoebae, plants, insects, and large animals. Progress in next-generation sequencing methods, together with microbial genome sequencing, has unveiled a wealth of natural products (NPs) with yet-untapped potential. Genome mining of Corallococcus species and the subspecies C. exiguus, known for their potential to produce clinically important secondary metabolites, has not been extensively studied. The goal of this study is to look into Corallococcus genomes’ biosynthetic gene clusters (BGCs) and carbohydrate-active enzyme gene clusters. We fully characterize BGCs from Corallococcus reference genome sequences that are publicly available using bioinformatic tools in addition to phylogenetic and genomic comparisons. Our results show that there is a huge range of BGCs in different Corallococcus genomes, but the species or subspecies level affects the ability to make NPs. Additionally, we investigated unknown and less comparable BGCs at the species level and found that C. llansteffanensis has more potential as a reservoir of new secondary metabolites. These insights will pave the way for the algorithmic identification of species- and subspecies-specific pathways for NP development.