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Objective <p>To assess the changes in Krebs von den Lungen-6 (KL-6) levels pre- and post-lung transplantation for interstitial lung disease and to determine the connection between changes in KL-6 levels and chronic lung allograft dysfunction.</p> Methods <p>Eighty-two lung transplantation procedures were performed in interstitial lung disease patients between January 2008 and December 2019. We compared changes in KL-6 levels before and after transplantation in two groups: unilateral and bilateral lung transplant groups. Additionally, KL-6 levels just before or at the onset of chronic lung allograft dysfunction were compared to the lowest post-transplant levels.</p> Results <p>In total, 28 female and 49 male patients (median age: 54&#xa0;years; range 22–64; 42 and 35 patients underwent unilateral and bilateral lung transplantations, respectively) were enrolled. The post-transplant observation period ranged from 8 to 163 (median: 64.2) months. KL-6 levels decreased in 76 patients (98.7%). Notably, the KL-6 level was lower in the bilateral lung transplantation group than in the unilateral lung transplantation group. Moreover, KL-6 levels were higher just before or at the onset of chronic lung allograft dysfunction than the lowest post-transplant levels. These levels were significantly higher than the highest post-transplant levels observed in the non-chronic lung allograft dysfunction group.</p> Conclusions <p>Our findings suggest that KL-6 levels decrease in interstitial lung disease patients following lung transplantation, with a greater reduction in KL-6 levels observed in bilateral lung transplantation compared to unilateral lung transplantation. Elevated serum KL-6 levels were associated with chronic lung allograft dysfunction, highlighting its utility as a diagnostic biomarker.</p>

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Trends in serum KL-6 levels following lung transplantation for interstitial lung diseases

  • 期刊论文

  • 发表日期：

    2025年2月24日

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  • Kazuhisa Matsumoto,
  • Akihiro Ohsumi,
  • Tomohiro Handa,
  • Daisuke Nakajima,
  • Satona Tanaka,
  • Satoshi Hamada,
  • Kohei Ikezoe,
  • Kiminobu Tanizawa,
  • Toyohiro Hirai,
  • Hiroshi Date

摘要

Objective

To assess the changes in Krebs von den Lungen-6 (KL-6) levels pre- and post-lung transplantation for interstitial lung disease and to determine the connection between changes in KL-6 levels and chronic lung allograft dysfunction.

Methods

Eighty-two lung transplantation procedures were performed in interstitial lung disease patients between January 2008 and December 2019. We compared changes in KL-6 levels before and after transplantation in two groups: unilateral and bilateral lung transplant groups. Additionally, KL-6 levels just before or at the onset of chronic lung allograft dysfunction were compared to the lowest post-transplant levels.

Results

In total, 28 female and 49 male patients (median age: 54 years; range 22–64; 42 and 35 patients underwent unilateral and bilateral lung transplantations, respectively) were enrolled. The post-transplant observation period ranged from 8 to 163 (median: 64.2) months. KL-6 levels decreased in 76 patients (98.7%). Notably, the KL-6 level was lower in the bilateral lung transplantation group than in the unilateral lung transplantation group. Moreover, KL-6 levels were higher just before or at the onset of chronic lung allograft dysfunction than the lowest post-transplant levels. These levels were significantly higher than the highest post-transplant levels observed in the non-chronic lung allograft dysfunction group.

Conclusions

Our findings suggest that KL-6 levels decrease in interstitial lung disease patients following lung transplantation, with a greater reduction in KL-6 levels observed in bilateral lung transplantation compared to unilateral lung transplantation. Elevated serum KL-6 levels were associated with chronic lung allograft dysfunction, highlighting its utility as a diagnostic biomarker.