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<p>Frailty is a complex syndrome marked by diminished physiological reserves and heightened susceptibility to negative health outcomes. The Atherogenic Index of Plasma (AIP), an indicator of lipid-associated cardiovascular and metabolic risk, has been widely studied in metabolic and cardiometabolic disorders; however, its relationship with frailty remains underexplored. This study seeks to investigate the association between AIP and frailty, as well as evaluate its viability as a predictive biomarker for frailty in older adults. This cross-sectional study encompassed 174 older adults from a geriatrics outpatient clinic. Frailty was evaluated with the Clinical Frailty Scale (CFS) version 2.0, whereas AIP was computed using the formula log(TG/HDL-C). Multivariable logistic regression analysis was conducted to determine independent factors that contribute to frailty. The efficacy of AIP in identifying frailty was assessed by receiver operating characteristic (ROC) curve analysis. Frailty was present in 29.3% (<i>n</i> = 51) of the participants. Logistic regression analysis identified AIP as an independent predictor of frailty (OR: 6.65, 95% CI 1.87–23.64, <i>p</i> = 0.003), along with lower Lawton–Brody Instrumental Activities of Daily Living (IADL) scores and lower Standardized Mini-Mental State Examination (SMMSE) scores. ROC analysis indicated that AIP predicted frailty with an AUC of 0.741 (95% CI 0.669–0.804, <i>p</i> &lt; 0.0001). AIP serves as an independent predictor of frailty, highlighting the significance of lipid metabolism in the pathophysiology of frailty. Due to its significant correlation with dyslipidemia, systemic inflammation, and oxidative stress, AIP may serve as an important biomarker for the early identification of frailty and risk assessment.</p>

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Predictive value of the atherogenic index of plasma for frailty in older adults

  • 期刊论文

  • 发表日期：

    2026年1月6日

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  • Ayse Dikmeer,
  • Zeynep Sahiner

摘要

Frailty is a complex syndrome marked by diminished physiological reserves and heightened susceptibility to negative health outcomes. The Atherogenic Index of Plasma (AIP), an indicator of lipid-associated cardiovascular and metabolic risk, has been widely studied in metabolic and cardiometabolic disorders; however, its relationship with frailty remains underexplored. This study seeks to investigate the association between AIP and frailty, as well as evaluate its viability as a predictive biomarker for frailty in older adults. This cross-sectional study encompassed 174 older adults from a geriatrics outpatient clinic. Frailty was evaluated with the Clinical Frailty Scale (CFS) version 2.0, whereas AIP was computed using the formula log(TG/HDL-C). Multivariable logistic regression analysis was conducted to determine independent factors that contribute to frailty. The efficacy of AIP in identifying frailty was assessed by receiver operating characteristic (ROC) curve analysis. Frailty was present in 29.3% (n = 51) of the participants. Logistic regression analysis identified AIP as an independent predictor of frailty (OR: 6.65, 95% CI 1.87–23.64, p = 0.003), along with lower Lawton–Brody Instrumental Activities of Daily Living (IADL) scores and lower Standardized Mini-Mental State Examination (SMMSE) scores. ROC analysis indicated that AIP predicted frailty with an AUC of 0.741 (95% CI 0.669–0.804, p < 0.0001). AIP serves as an independent predictor of frailty, highlighting the significance of lipid metabolism in the pathophysiology of frailty. Due to its significant correlation with dyslipidemia, systemic inflammation, and oxidative stress, AIP may serve as an important biomarker for the early identification of frailty and risk assessment.