<p>2030 Agenda Sustainable Development Goals (SDGs) achievement is the main challenge in order to design a sustainable future society. SDG 3 ensure healthy lives and promote well-being for all at all ages, focusing on prevention and treatment of communicable diseases (CDs) and non-communicable diseases (NCDs). Moreover, access to care, affordable drugs, and vaccines is crucial to improve quality of life leaving no one behind. Internal medicine can answer to the United Nations (UN) universal call by taking action both on infectious disease burden and on NCDs challenge, enabling prevention strategies and treatments, providing new drugs and ensuring accessible care for all. Furthermore, thanks to internist holistic and patient-centered approach, together with a multidisciplinary strategy, misallocation of economic and human resources, and medical errors due to healthcare fragmentation could be avoided. Nonetheless, a syndemic approach taking into account economic, social, and environmental dimensions of health will become fundamental for healthcare systems design. In this framework, internal medicine will be crucial giving a comprehensive patient-centered perspective, coordinating multidisciplinary team interventions, and contributing to sustainable healthcare systems.</p> Graphical abstract <p>Prevalence of major global causes of death by groups in 2021 according to Wolrd Health Organization World Health Statistics 2024 [12]; Internal Medicine characteristics; Internal Medicine-related SDGs summary; Future challenges for Internal Medicine</p>