Objective <p>To observe the clinical efficacy of modified painless suppurative moxibustion with wheat-grain sized moxa cones plus Western medication in treating cough variant asthma (CVA) due to wind-cold attacking the lung and its effects on pulmonary function, serum immunoglobulin (Ig)-E, hypersensitive C-reactive protein (hs-CRP), and interleukin (IL)-6.</p> Methods <p>A total of 98 CVA patients were randomly divided into an observation group and a control group using the random number table method, with 49 cases in each group. The control group was treated with salmeterol xinafoate and fluticasone propionate powder for inhalation, and the observation group was treated with additional modified painless suppurative moxibustion with wheat-grain sized moxa cones. The treatment lasted for 8 weeks. The traditional Chinese medicine (TCM) symptom score of the patients in both groups was observed before treatment, after treatment, and at 1-month follow-up after treatment for its changes. The clinical efficacy after treatment and at 1-month follow-up was compared between the two groups. The pulmonary function [forced expiratory volume in the first second (FEV1), FEV1/forced vital capacity (FVC), and peak expiratory flow (PEF)] and serum IgE, hs-CRP, and IL-6 levels were compared between the two groups before and after treatment. The adverse reactions that occurred during the treatment in both groups were observed and recorded.</p> Results <p>The total effective rate of the observation group after treatment and at follow-up was higher than that of the control group (<i>P</i>&lt;0.05). The TCM symptom scores in both groups after treatment and at follow-up were lower compared to the baseline (<i>P</i>&lt;0.05), and the scores in the observation group were lower than those in the control group (<i>P</i>&lt;0.05). The FEV1, FEV1/FVC, and PEF after treatment in both groups were higher compared to the baseline (<i>P</i>&lt;0.05), and the levels in the observation group were higher than those in the control group (<i>P</i>&lt;0.05). The serum levels of IgE, IL-6, and hs-CRP after treatment in both groups were lower than the baseline (<i>P</i>&lt;0.05), and the levels in the observation group were lower than those in the control group (<i>P</i>&lt;0.05). There were no adverse reactions in either group during the course of the study.</p> Conclusion <p>Modified painless suppurative moxibustion with wheat-grain sized moxa cones plus salmeterol xinafoate and fluticasone propionate powder for inhalation is effective in treating CVA due to wind-cold attacking the lung; it can relieve the clinical symptoms of the patients, improve their pulmonary function, and also reduce serum IgE, hs-CRP, and IL-6 levels.</p>