Scholarlink

<p>Two-dimensional (2D) Nb<sub>2</sub>CT<sub><i>x</i></sub> MXene hold great promise for biomedical applications due to their tunable surface chemistry and biocompatibility. However, their practical use requires long-term colloidal and oxidative stability. Here, we propose a tandem-type stabilization strategy combining antioxidant protection and macromolecular surface functionalization. Nb<sub>2</sub>CT<sub><i>x</i></sub> was first treated with L-ascorbic acid (LA) to suppress oxidation by binding to reactive edges, followed by modification with polyethylene glycol (PEG), poly-L-lysine (PLL), or polydopamine (PDA). This dual approach enhanced stability in biological media — phosphate-buffered saline (PBS) and Dulbecco’s Modified Eagle’s Medium (DMEM) — while preserving non-cytotoxicity toward A375 and HaCaT skin cell lines across 0–100 mg·L<sup>−1</sup>. Among the tested systems, LA/PEG and LA/PDA-modified MXenes maintained stable zeta potentials (−15 to −12 mV) and particle sizes for 72 h, whereas LA/PLL samples showed aggregation and charge loss. This tandem stabilization effectively prevents oxidation and aggregation without compromising biocompatibility, offering a versatile route for developing oxidation-resistant MXenes for biomedical and nanomedicine applications.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Effect of tandem-type stabilization of Nb2CTx MXene on their colloidal and cytotoxic properties

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月16日

查看全文
  • M. Jakubczak,
  • A. Wojciechowska,
  • J. Mitrzak,
  • A. Szuplewska,
  • M. Chudy,
  • A. Wójcik,
  • D. Moszczyńska,
  • K. Prenger,
  • M. Naguib,
  • A. M. Jastrzębska

摘要

Two-dimensional (2D) Nb2CTx MXene hold great promise for biomedical applications due to their tunable surface chemistry and biocompatibility. However, their practical use requires long-term colloidal and oxidative stability. Here, we propose a tandem-type stabilization strategy combining antioxidant protection and macromolecular surface functionalization. Nb2CTx was first treated with L-ascorbic acid (LA) to suppress oxidation by binding to reactive edges, followed by modification with polyethylene glycol (PEG), poly-L-lysine (PLL), or polydopamine (PDA). This dual approach enhanced stability in biological media — phosphate-buffered saline (PBS) and Dulbecco’s Modified Eagle’s Medium (DMEM) — while preserving non-cytotoxicity toward A375 and HaCaT skin cell lines across 0–100 mg·L−1. Among the tested systems, LA/PEG and LA/PDA-modified MXenes maintained stable zeta potentials (−15 to −12 mV) and particle sizes for 72 h, whereas LA/PLL samples showed aggregation and charge loss. This tandem stabilization effectively prevents oxidation and aggregation without compromising biocompatibility, offering a versatile route for developing oxidation-resistant MXenes for biomedical and nanomedicine applications.