<p>We sought to investigate if robotic mitral surgery had a positive impact on postoperative quality of life. Patients who underwent isolated mitral repair or replacement in our institution since 2020 were offered to participate. A previously validated quality-of-life questionnaire (SF-36) was given to the patients at different postoperative timeframes (preoperative, 15&#xa0;days, 3, 6&#xa0;months after surgery). Patients were divided in 2 groups depending on the surgical approach (robotic-R; <i>n</i> = 85 or video-assisted thoracotomy-VAT; <i>n</i> = 32). Data are presented as counts (percentages) or median (IQR); comparisons were made using the Chi-square test or Mann–Whitney U test. There were no major preoperative differences in clinical or in any of three 8 items between groups, except for a trend toward better physical role in the R-group. In all 15&#xa0;days, both groups showed declined in physical role and increase in bodily pain; furthermore, vitality, social function, emotional role, and mental health seemed worse in the VAT-group. Three months after surgery, physical function has improved compared to baseline in the R-group but not the VAT-groups. Physical function recovered, but mostly in R-group and both groups improved in pain levels. Finally, at 6&#xa0;months, most values had return to baseline levels in both groups, except for global health, which is lower in VAT-group. Despite the study limitations, the robotic approach seems to provide a better postoperative recovery and thus and improved quality of life compared to a video-assisted thoracotomy approach. Further studies are needed to confirm the findings.</p>