<p>Vitamin D is a thermolabile micronutrient whose stability in enriched products remains a critical concern during processing and storage. Despite its relevance and widespread use, comprehensive kinetic data describing its thermal instability (thermal isomerization and oxidative and thermal degradation) are rather inconsistent. A review of the literature covering the period 2000–2026 indicates that a large number of studies have applied a first-order reaction model with Arrhenius temperature dependence to describe vitamin D kinetics. However, the applicability of this approach may be limited in complex matrices, where multistep reaction pathways, diffusion limitations, or non-Arrhenius behavior can occur. The kinetic behavior of vitamin D is strongly influenced by several factors, including the matrix composition, temperature, moisture content, and other environmental conditions, leading to substantial variability in the reported kinetic parameters. Reported activation energies for the thermal degradation of vitamin D₃ in supplements span a wide range, approximately from 89 to 300&#xa0;kJ mol⁻¹, reflecting differences in experimental systems and conditions. Consequently, the accurate prediction of thermal stability and shelf-life of vitamin D-containing materials remains a continuing scientific and technological challenge. Computational modeling with model-free and model-fitting methods enables the determination of the activation energy (Ea), preexponential factors (A) and reaction mechanisms (f(α)) for such complex systems. These kinetic parameters enable predictive modeling of vitamin D degradation under various thermal conditions, offering insight into stability and, in turn, providing information for optimized formulation, processing, and storage strategies that can be directly applied in industry.</p>