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<p>Kidney disease represents a growing health issue worldwide, frequently caused by oxidative stress and inflammatory reactions. Botanical sources of antioxidants offer new therapeutic options. <i>Cleome viscosa</i> L. (Spider Flower) has traditionally been utilized in the treatment of inflammatory conditions and metabolic diseases. In the current study, the antioxidant, anti-inflammatory, antimicrobial, and cytoprotective effects of the crude ethanolic extract of <i>C</i>. <i>viscosa</i> flowers were examined <i>in vitro</i>. Phytochemical screening indicated the presence of flavonoids, phenolic compounds, alkaloids, and tannins. The IC<sub>50</sub> values for DPPH radical scavenging and protein denaturation were 46.2 ± 2.1&#xa0;µg/mL and 43.5 ± 1.8&#xa0;µg/mL, respectively. The total phenolic and total flavonoid contents were 90.00 ± 14.14&#xa0;mg GAE/g and 70.00 ± 4.24&#xa0;mg QE/g, respectively. The crude ethanolic extract exhibited minimal cytotoxicity on Vero cells (IC<sub>50</sub> &gt; 200&#xa0;µg/mL) and promoted wound healing (78.4 % after 24&#xa0;h). Thus, the flowers of <i>C</i>. <i>viscosa</i> possess a rich composition of phytochemicals with antioxidant, anti-inflammatory, and cytoprotective properties. These findings suggest that <i>C</i>. <i>viscosa</i> flowers contain bioactive phytochemicals with significant therapeutic potential.</p>

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In vitro assessment of the antioxidant, anti-inflammatory, and cytoprotective activities of Cleome viscosa flower extract

  • 期刊论文

  • 发表日期：

    2026年7月13日

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  • D. Hariharan,
  • J. Reshma,
  • Ashish Kumar Nayak,
  • P. Saranraj,
  • B. Lokeshwari

摘要

Kidney disease represents a growing health issue worldwide, frequently caused by oxidative stress and inflammatory reactions. Botanical sources of antioxidants offer new therapeutic options. Cleome viscosa L. (Spider Flower) has traditionally been utilized in the treatment of inflammatory conditions and metabolic diseases. In the current study, the antioxidant, anti-inflammatory, antimicrobial, and cytoprotective effects of the crude ethanolic extract of C. viscosa flowers were examined in vitro. Phytochemical screening indicated the presence of flavonoids, phenolic compounds, alkaloids, and tannins. The IC50 values for DPPH radical scavenging and protein denaturation were 46.2 ± 2.1 µg/mL and 43.5 ± 1.8 µg/mL, respectively. The total phenolic and total flavonoid contents were 90.00 ± 14.14 mg GAE/g and 70.00 ± 4.24 mg QE/g, respectively. The crude ethanolic extract exhibited minimal cytotoxicity on Vero cells (IC50 > 200 µg/mL) and promoted wound healing (78.4 % after 24 h). Thus, the flowers of C. viscosa possess a rich composition of phytochemicals with antioxidant, anti-inflammatory, and cytoprotective properties. These findings suggest that C. viscosa flowers contain bioactive phytochemicals with significant therapeutic potential.