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<p>Hybrid materials made from inorganic compounds which have drawn a substantial interest, because of their special structure and biological features. In this work, polyoxometalates of STA family hybrid materials doped with transition metals, namely copper, manganese, and vanadium, with benzoguanamine as the organic unit have been synthesized. Characterization of the synthesized samples was performed using FT-IR, UV–Vis spectroscopy, powder XRD, and thermogravimetric analysis. Thermal analysis indicated that the stability of the complexes followed the order STVPt &lt; STCuPt &lt; STMnPt, with percentage stability values of 42.42%, 53.94%and 61.37%, respectively, The SEM reveals morphology changes associated with metal incorporation, while EDX data confirm the elemental composition of the synthesized materials. The hybrid materials synthesized were evaluated for their antibacterial activity against S. aureus and E. coli. The outcomes demonstrated the enhanced antibacterial activity which may be related to the presence of metal, containing polyoxometalate with organic moiety. The antioxidant activity was assessed through the DPPH radical scavenging assay, using ascorbic acid as reference standard. The MTT assay was used for cytotoxicity studies against MCF-7 breast cancer cells after 24&#xa0;h of treatment. STMnPt and STVPt were found to be the only compounds with cytotoxic activity with IC<sub>50</sub> of 189.2&#xa0;µg/mL and 77.60&#xa0;µg/mL, respectively. Whereas STCuPt doesn’t shown the toxicity toward the tested cell line. The obtained results suggest that these hybrid materials may have potential for further biological investigations.</p> Graphical abstract <p></p>

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Synthesis, characterization and biological evaluation of transition metal (Cu, Mn, V) substituted silverton type anion based benzoguanamine hybrid materials

  • 期刊论文

  • 发表日期：

    2026年7月13日

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  • Rajesh Kumar,
  • S. Jemimah Lims,
  • Alphonse Lazar,
  • Yi-Li Lin,
  • Bharath Samannan,
  • Jeyabalan Thavasikani

摘要

Hybrid materials made from inorganic compounds which have drawn a substantial interest, because of their special structure and biological features. In this work, polyoxometalates of STA family hybrid materials doped with transition metals, namely copper, manganese, and vanadium, with benzoguanamine as the organic unit have been synthesized. Characterization of the synthesized samples was performed using FT-IR, UV–Vis spectroscopy, powder XRD, and thermogravimetric analysis. Thermal analysis indicated that the stability of the complexes followed the order STVPt < STCuPt < STMnPt, with percentage stability values of 42.42%, 53.94%and 61.37%, respectively, The SEM reveals morphology changes associated with metal incorporation, while EDX data confirm the elemental composition of the synthesized materials. The hybrid materials synthesized were evaluated for their antibacterial activity against S. aureus and E. coli. The outcomes demonstrated the enhanced antibacterial activity which may be related to the presence of metal, containing polyoxometalate with organic moiety. The antioxidant activity was assessed through the DPPH radical scavenging assay, using ascorbic acid as reference standard. The MTT assay was used for cytotoxicity studies against MCF-7 breast cancer cells after 24 h of treatment. STMnPt and STVPt were found to be the only compounds with cytotoxic activity with IC50 of 189.2 µg/mL and 77.60 µg/mL, respectively. Whereas STCuPt doesn’t shown the toxicity toward the tested cell line. The obtained results suggest that these hybrid materials may have potential for further biological investigations.

Graphical abstract