Scholarlink

<p>Designing copper-based coordination complexes with controlled particle size is important for understanding their potential influence on anticancer activity and toxicity toward normal cells. In this work, a Cu(II)-ciprofloxacin/decanoate (Cu(II)-CP/DA) coordination system containing nanoscale Cu-based domains was synthesized via electrochemical Cu<sup>2</sup>⁺ generation, enabling modulation of particle size through variation of applied voltage (1–10&#xa0;V) and electrolyte concentration (0.01–0.5&#xa0;M KNO<sub>3</sub>). TEM and FESEM analyses indicated that lower electrochemical driving forces were associated with smaller observed Cu-containing nanoscale features, whereas higher applied conditions resulted in more aggregated features and rougher surface morphologies. Furthermore, structural characterization using ATR-FTIR, UV–Vis, and XRD revealed carboxylate vibration shifts, absorption changes, Cu(II) <i>d–d</i> transitions, and XRD peak shifts that are consistent with Cu(II)–ligand coordination. Collectively, these observations suggest complex formation rather than a simple physical mixture of the precursor components. Biological evaluation showed that particle size variation significantly influenced anticancer response. The smallest-sized complex (Cu1; 2.14 ± 1.40&#xa0;nm), which exhibited the lowest IC<sub>50</sub> value (12.85&#xa0;µM), showed the strongest inhibitory effect toward MCF 7 breast cancer cells, reducing viability to below 30% after 72&#xa0;h, while MCF 10A normal epithelial cells maintained viability above 90% under the same conditions. The observed biological differences are likely influenced by multiple physicochemical factors associated with particle size variation, although the exact mechanism was not investigated. Overall, these results demonstrate that electrochemical synthesis parameters can tune nanoscale characteristics and biological responses in Cu(II)-CP/DA coordination systems, supporting their potential for further exploration in Cu-based anticancer materials.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Particle size-controlled Cu(II)-ciprofloxacin/decanoate complexes: structural features and selective growth inhibition of breast cancer cell

  • 期刊论文

  • 发表日期：

    2026年6月26日

查看全文
  • Hanisah Abdul Rahim,
  • Norazzizi Nordin,
  • Badrul Hisham Yahaya,
  • Azizul Hakim Lahuri,
  • Mohamad Nurul Azmi Mohamad Taib,
  • Wan Zurina Samad

摘要

Designing copper-based coordination complexes with controlled particle size is important for understanding their potential influence on anticancer activity and toxicity toward normal cells. In this work, a Cu(II)-ciprofloxacin/decanoate (Cu(II)-CP/DA) coordination system containing nanoscale Cu-based domains was synthesized via electrochemical Cu2⁺ generation, enabling modulation of particle size through variation of applied voltage (1–10 V) and electrolyte concentration (0.01–0.5 M KNO3). TEM and FESEM analyses indicated that lower electrochemical driving forces were associated with smaller observed Cu-containing nanoscale features, whereas higher applied conditions resulted in more aggregated features and rougher surface morphologies. Furthermore, structural characterization using ATR-FTIR, UV–Vis, and XRD revealed carboxylate vibration shifts, absorption changes, Cu(II) d–d transitions, and XRD peak shifts that are consistent with Cu(II)–ligand coordination. Collectively, these observations suggest complex formation rather than a simple physical mixture of the precursor components. Biological evaluation showed that particle size variation significantly influenced anticancer response. The smallest-sized complex (Cu1; 2.14 ± 1.40 nm), which exhibited the lowest IC50 value (12.85 µM), showed the strongest inhibitory effect toward MCF 7 breast cancer cells, reducing viability to below 30% after 72 h, while MCF 10A normal epithelial cells maintained viability above 90% under the same conditions. The observed biological differences are likely influenced by multiple physicochemical factors associated with particle size variation, although the exact mechanism was not investigated. Overall, these results demonstrate that electrochemical synthesis parameters can tune nanoscale characteristics and biological responses in Cu(II)-CP/DA coordination systems, supporting their potential for further exploration in Cu-based anticancer materials.