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<p>In this study, a pH-responsive drug delivery system (DDS) based on octa-aminopropyl polyhedral oligomeric silsesquioxane (OA-POSS), dextran (Dex), and magnetic nanoparticles (MNPs) was developed for potential cancer therapy applications. Fe<sub>3</sub>O<sub>4</sub> NPs were initially synthesized and subsequently functionalized with dextran dialdehyde (Dex-DA) and OA-POSS through a Schiff-base imine reaction, yielding the Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub>@Dex-DA@OA-POSS nanocarrier (NC). Doxorubicin (DOX), used as a model anticancer agent, was successfully loaded onto the NC via noncovalent physical interactions, achieving a high drug encapsulation efficiency (DEE) of approximately 95%. The synthesized NCs were characterized using FT-IR, FE-SEM, DLS, XRD, and VSM techniques. In vitro drug release studies demonstrated pronounced pH-responsive behavior. At physiological pH (7.4), less than 15% of DOX was released, whereas under acidic conditions (pH 5), approximately 81% of the drug was released over a period 6 days. Cytotoxicity assessments revealed that the blank Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub>@Dex-DA@OA-POSS NCs were biocompatible with cell viability above 85%. In contrast, DOX-loaded NCs exhibited strong anticancer activity against A549 cells, with an IC<sub>50</sub> value of around 1 µg/mL, attributed to the controlled release of DOX. Overall, the Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub>@Dex-DA@OA-POSS/DOX NC shows promising potential as a targeted and stimuli-responsive drug delivery platform for cancer treatment.</p>

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Octa-aminopropyl polyhedral oligomeric silsesquioxane-functionalized magnetic dextran nanoparticles via dynamic Schiff-base imine bonds for sustained doxorubicin release

  • 期刊论文

  • 发表日期：

    2026年6月29日

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  • Ramezan Ali Taheri,
  • Ali Mohammadzadeh,
  • Reza Mohammadi,
  • Ramin Karimian,
  • Mohammad Reza Khodabakhshi

摘要

In this study, a pH-responsive drug delivery system (DDS) based on octa-aminopropyl polyhedral oligomeric silsesquioxane (OA-POSS), dextran (Dex), and magnetic nanoparticles (MNPs) was developed for potential cancer therapy applications. Fe3O4 NPs were initially synthesized and subsequently functionalized with dextran dialdehyde (Dex-DA) and OA-POSS through a Schiff-base imine reaction, yielding the Fe3O4@SiO2@Dex-DA@OA-POSS nanocarrier (NC). Doxorubicin (DOX), used as a model anticancer agent, was successfully loaded onto the NC via noncovalent physical interactions, achieving a high drug encapsulation efficiency (DEE) of approximately 95%. The synthesized NCs were characterized using FT-IR, FE-SEM, DLS, XRD, and VSM techniques. In vitro drug release studies demonstrated pronounced pH-responsive behavior. At physiological pH (7.4), less than 15% of DOX was released, whereas under acidic conditions (pH 5), approximately 81% of the drug was released over a period 6 days. Cytotoxicity assessments revealed that the blank Fe3O4@SiO2@Dex-DA@OA-POSS NCs were biocompatible with cell viability above 85%. In contrast, DOX-loaded NCs exhibited strong anticancer activity against A549 cells, with an IC50 value of around 1 µg/mL, attributed to the controlled release of DOX. Overall, the Fe3O4@SiO2@Dex-DA@OA-POSS/DOX NC shows promising potential as a targeted and stimuli-responsive drug delivery platform for cancer treatment.