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<p>The utilization of carbon dots (CDs) as an analytical probe in sensing applications has been made viable owing to their distinct photophysical properties. The current work proposes the use of Soursop (<i>Annona muricata</i>) leaves are known for their traditional medicinal uses and contain various bioactive compounds with potential health benefits. They have been traditionally used to treat inflammatory conditions, neuralgia, diabetes, and even cancer. Phytochemical analysis has revealed the presence of compounds like alkaloids, flavonoids, phenols, and steroids, which contribute to their antioxidant and other biological activities. Analysis of photo-physical and structural properties verified the production of CDs, which demonstrated 2–5&#xa0;nm size range. Additionally, the CDs were investigated as an analytical probe by using UV spectroscopy to detect 5-fluorouracil (5-FU), an anticancer medication. The produced soursop carbon dots (SSCDs) exhibiting remarkable optical properties emerged as a promising sensing probe for 5-FU in the range of 5 to 50&#xa0;µmol L<sup>−1</sup>, quantum yield 12.65%, and with a lower detection limit of 1.41&#xa0;µmol L<sup>−1</sup>. Additionally, the various counter ions were examined for potential interference with the detection. The method showed satisfactory recovery (≈ 95%) in pharmaceutical formulations, indicating its practical applicability. Additionally, the SSCDs exhibited good stability and reproducibility over time. The ongoing research offers a UV-based sensor for the quantitative and selective detection of 5-FU, which is a rapid, straightforward, affordable, and robust sensing probe.</p> Graphical abstract <p></p>

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Soursop leaves derived carbon dots probe for efficient sensing of 5-fluorouracil anticancer drug

  • 期刊论文

  • 发表日期：

    2026年5月11日

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  • Pradnya Khandagale,
  • Archana Kanthe,
  • Prasad Mahajan,
  • Vijay Sawant,
  • Rohant Dhabbe,
  • Rajratna Kakade,
  • Ramesh Yelgudre,
  • Sandip Nipane,
  • Sandip Sabale,
  • Deok-kee Kim

摘要

The utilization of carbon dots (CDs) as an analytical probe in sensing applications has been made viable owing to their distinct photophysical properties. The current work proposes the use of Soursop (Annona muricata) leaves are known for their traditional medicinal uses and contain various bioactive compounds with potential health benefits. They have been traditionally used to treat inflammatory conditions, neuralgia, diabetes, and even cancer. Phytochemical analysis has revealed the presence of compounds like alkaloids, flavonoids, phenols, and steroids, which contribute to their antioxidant and other biological activities. Analysis of photo-physical and structural properties verified the production of CDs, which demonstrated 2–5 nm size range. Additionally, the CDs were investigated as an analytical probe by using UV spectroscopy to detect 5-fluorouracil (5-FU), an anticancer medication. The produced soursop carbon dots (SSCDs) exhibiting remarkable optical properties emerged as a promising sensing probe for 5-FU in the range of 5 to 50 µmol L−1, quantum yield 12.65%, and with a lower detection limit of 1.41 µmol L−1. Additionally, the various counter ions were examined for potential interference with the detection. The method showed satisfactory recovery (≈ 95%) in pharmaceutical formulations, indicating its practical applicability. Additionally, the SSCDs exhibited good stability and reproducibility over time. The ongoing research offers a UV-based sensor for the quantitative and selective detection of 5-FU, which is a rapid, straightforward, affordable, and robust sensing probe.

Graphical abstract