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<p>In this study, a novel dispersive magnetic solid-phase extraction (DMSPE) method utilizing a magnetite/clinoptilolite zeolite nanocomposite was developed for the extraction and pre-concentration of triptorelin acetate (TA) from aqueous solutions. The pre-concentrated analyte was quantified using high-performance liquid chromatography with ultraviolet detection (HPLC-UV). The magnetic nanocomposite was synthesized and characterized for its structural, morphological, and magnetic properties using field emission scanning electron microscopy (FESEM), powder X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), nitrogen adsorption–desorption isotherms (BET), and vibrating sample magnetometry (VSM). Key parameters affecting extraction efficiency including pH, temperature, extraction and desorption times, sorbent amount, and the type, volume, and concentration of the eluent were systematically investigated and optimized. Method validation was performed under optimal conditions. The calibration curve for TA was linear over the range of 5.0–250.0 ng mL<sup>‒1</sup> with a correlation coefficient of 0.9988. The DMSPE–HPLC-UV method achieved a detection limit of 1.1 ng mL<sup>‒1</sup> and a pre-concentration factor of 100. Its applicability was demonstrated by successfully detecting TA in various urine samples.</p>

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An efficient DMSPE technique based on magnetite/clinoptilolite zeolite nanocomposite for the pre-concentration of triptorelin in urine samples

  • 期刊论文

  • 发表日期：

    2025年12月20日

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  • Hossein Abdolmohammad-Zadeh,
  • Hamid Mobedi,
  • Elahe Mobedi

摘要

In this study, a novel dispersive magnetic solid-phase extraction (DMSPE) method utilizing a magnetite/clinoptilolite zeolite nanocomposite was developed for the extraction and pre-concentration of triptorelin acetate (TA) from aqueous solutions. The pre-concentrated analyte was quantified using high-performance liquid chromatography with ultraviolet detection (HPLC-UV). The magnetic nanocomposite was synthesized and characterized for its structural, morphological, and magnetic properties using field emission scanning electron microscopy (FESEM), powder X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), nitrogen adsorption–desorption isotherms (BET), and vibrating sample magnetometry (VSM). Key parameters affecting extraction efficiency including pH, temperature, extraction and desorption times, sorbent amount, and the type, volume, and concentration of the eluent were systematically investigated and optimized. Method validation was performed under optimal conditions. The calibration curve for TA was linear over the range of 5.0–250.0 ng mL‒1 with a correlation coefficient of 0.9988. The DMSPE–HPLC-UV method achieved a detection limit of 1.1 ng mL‒1 and a pre-concentration factor of 100. Its applicability was demonstrated by successfully detecting TA in various urine samples.