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<p>This research presents how to synthesize and characterize the 4,4’,4’’-(2,4,6-trimethyl-1,3,5-benzenetriyl)tris-pyridinium sulfonic acid tri-triflate (TMBTPST) salt as a novel and eco-friendly catalyst for the synthesis of pyrido[2,3-<i>d</i>:6,5-<i>d′</i>]dipyrimidines, and pyrido[2,3-<i>d</i>]pyrimidines. TMBTPST was characterized by various physicochemical methods. The results showed that this repeatable salt is capable of rapidly producing pyridine derivatives in excellent yields under environmental conditions consistent with green chemistry criteria (<b>4a-4n</b>: 89 to 98%, 4 to 10&#xa0;min, and <b>7a-7&#xa0;L</b>: 88 to 98%, 5 to 13&#xa0;min). These conditions were achieved through the use of a safe aqueous medium, the non-metallic nature of catalyst, mild temperature conditions (25 to 50&#xa0;°C), and the synthesis of the products <i>via</i> a clean one-pot multicomponent approach without the generation of by-products.</p> Graphical abstract <p></p>

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Rapid synthesis of pyrimidine derivatives using a reproducible catalyst based on triflate anion

  • 期刊论文

  • 发表日期：

    2025年12月9日

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  • Ebraheem Abdu Musad Saleh,
  • M. M. Moharam,
  • Fadhel F. Seed,
  • R. Roopashree,
  • Subhashree Ray,
  • Karthikeyan Jayabalan,
  • Renu Sharma,
  • Aashna Sinha,
  • I. B. Sapaev,
  • Devendra Pratap Rao

摘要

This research presents how to synthesize and characterize the 4,4’,4’’-(2,4,6-trimethyl-1,3,5-benzenetriyl)tris-pyridinium sulfonic acid tri-triflate (TMBTPST) salt as a novel and eco-friendly catalyst for the synthesis of pyrido[2,3-d:6,5-d′]dipyrimidines, and pyrido[2,3-d]pyrimidines. TMBTPST was characterized by various physicochemical methods. The results showed that this repeatable salt is capable of rapidly producing pyridine derivatives in excellent yields under environmental conditions consistent with green chemistry criteria (4a-4n: 89 to 98%, 4 to 10 min, and 7a-7 L: 88 to 98%, 5 to 13 min). These conditions were achieved through the use of a safe aqueous medium, the non-metallic nature of catalyst, mild temperature conditions (25 to 50 °C), and the synthesis of the products via a clean one-pot multicomponent approach without the generation of by-products.

Graphical abstract