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<p>The present article developed a highly sensitive DNA biosensor using modified screen-printed electrode (SPE) with polypyrrole (PP), praseodymium doped nanoneedle-assembled hierarchical NiO nanoflower (Pr<sup>3+</sup>/N-A H NiO NF) and ds-DNA to detect Cabozantinib as an anticancer drug. The ds-DNA/PP/Pr<sup>3+</sup>/N-A H NiO NF/SPE biosensor was created through a layer-by-layer fabrication process. Moreover, successful synthesis of Pr<sup>3+</sup>/N-A H NiO NF were verified by physicochemical characterization methods. The electrochemical impedance spectroscopy (EIS) revealed the ability of the modified SPE to reduce charge transfer resistance, resulting from the facilitated particle transfer and enhanced electrical conductivity. The biosensor accurately determined Cabozantinib within a range between 0.001 and 400.0&#xa0;μM and LOD of 0.11&#xa0;nM. It also effectively monitored Cabozantinib in real samples, with a recovery range between 98.0 and 100.8%.</p>

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A sensitive guanine-based DNA-biosensor to monitor Cabozantinib anticancer in biological samples

  • 期刊论文

  • 发表日期：

    2026年2月5日

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  • Mohamed J. Saadh,
  • Nadhir N. A. Jafar,
  • Nizar Jawad,
  • Farag M. A. Altalbawy,
  • Ghassan Ali Dayeh,
  • Mandeep Kaur,
  • Ali G. Alkhathami,
  • Ali Altharawi

摘要

The present article developed a highly sensitive DNA biosensor using modified screen-printed electrode (SPE) with polypyrrole (PP), praseodymium doped nanoneedle-assembled hierarchical NiO nanoflower (Pr3+/N-A H NiO NF) and ds-DNA to detect Cabozantinib as an anticancer drug. The ds-DNA/PP/Pr3+/N-A H NiO NF/SPE biosensor was created through a layer-by-layer fabrication process. Moreover, successful synthesis of Pr3+/N-A H NiO NF were verified by physicochemical characterization methods. The electrochemical impedance spectroscopy (EIS) revealed the ability of the modified SPE to reduce charge transfer resistance, resulting from the facilitated particle transfer and enhanced electrical conductivity. The biosensor accurately determined Cabozantinib within a range between 0.001 and 400.0 μM and LOD of 0.11 nM. It also effectively monitored Cabozantinib in real samples, with a recovery range between 98.0 and 100.8%.