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<p>Nitrogen-containing heterocycles are crucial in agrochemicals, material science, pharmaceuticals, and biologicals process, making them a major focus of research and development. The present review outlines recent methods for the synthesis of 1,2,3-triazolines through cycloaddition and their different properties published over the past decade. The supplied data demonstrate the various routes to synthesize 1,2,3-triazolines core such as 1,3-dipolar cycloaddition of azide/alkene or diazo group compound/Schiff base. This highlights the vast potential of these heterocycles derivatives for the design of potent bioactive molecules.</p> Graphical abstract <p></p>

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A decade of advances in the synthesis and biological potential of 1,2,3-triazolines

  • 期刊论文

  • 发表日期：

    2025年9月22日

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  • Yasmine Rahma Hachemi,
  • Mohammed Hamadouche

摘要

Nitrogen-containing heterocycles are crucial in agrochemicals, material science, pharmaceuticals, and biologicals process, making them a major focus of research and development. The present review outlines recent methods for the synthesis of 1,2,3-triazolines through cycloaddition and their different properties published over the past decade. The supplied data demonstrate the various routes to synthesize 1,2,3-triazolines core such as 1,3-dipolar cycloaddition of azide/alkene or diazo group compound/Schiff base. This highlights the vast potential of these heterocycles derivatives for the design of potent bioactive molecules.

Graphical abstract