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<p>Current research focuses on the antisolvent precipitation of Fenofibrate via microfluidics for dissolution enhancement and <i>In-Vitro</i> release&#xa0;study. Microfluidic system as a process intensification was customized based on the molecular diffusivity, mixing mechanism of the organic-aqueous phases, Fourier number, and Dean number. A 3D-printed T-micromixer (contact angle of micromixer 180°), followed by a meander-shaped silicon tube microchannel, was taken for the microfluidic mixing. One factor at a time, followed by response surface methodology, was applied for the parametric and optimization studies&#xa0;respectively. The effect of parameters: microchannel length, drug concentration, carrier-drug ratio, and aqueous organic phase ratio on the particle size were studied. Particle size, polydispersity index, zeta potential, scanning electron microscopy, fourier-transform infrared spectra, X-ray diffraction were analyzed for raw and optimized Fenofibrate formulation. The <i>In-Vitro</i> release of optimized Fenofibrate formulation resulted in 99.88% release in 5.5&#xa0;h. The release followed the Korsmeyer-Peppas kinetic model with a transport constant (k<sub>KP</sub>) of 53.83 (time<sup>−1</sup>) and transport exponent (n) of 0.35, satisfying a diffusion dissolution-dependent model.</p>

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Microfluidic precipitation of Fenofibrate for dissolution enhancement and In-Vitro release study: an OFAT followed by RSM approach

  • 期刊论文

  • 发表日期：

    2025年9月21日

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  • Rashmita Behera,
  • Sanjaykumar R. Patel

摘要

Current research focuses on the antisolvent precipitation of Fenofibrate via microfluidics for dissolution enhancement and In-Vitro release study. Microfluidic system as a process intensification was customized based on the molecular diffusivity, mixing mechanism of the organic-aqueous phases, Fourier number, and Dean number. A 3D-printed T-micromixer (contact angle of micromixer 180°), followed by a meander-shaped silicon tube microchannel, was taken for the microfluidic mixing. One factor at a time, followed by response surface methodology, was applied for the parametric and optimization studies respectively. The effect of parameters: microchannel length, drug concentration, carrier-drug ratio, and aqueous organic phase ratio on the particle size were studied. Particle size, polydispersity index, zeta potential, scanning electron microscopy, fourier-transform infrared spectra, X-ray diffraction were analyzed for raw and optimized Fenofibrate formulation. The In-Vitro release of optimized Fenofibrate formulation resulted in 99.88% release in 5.5 h. The release followed the Korsmeyer-Peppas kinetic model with a transport constant (kKP) of 53.83 (time−1) and transport exponent (n) of 0.35, satisfying a diffusion dissolution-dependent model.