Scholarlink

<p>A novel and sensitive electrochemical sensor was developed for the detection of L-Tyrosine (LTRS), utilizing a composite of Graphene Oxide, Graphitic Carbon Nitride, and Zinc Oxide to functionalize a Glassy Carbon Electrode (GCE). The modified GCE exhibited significantly enhanced electrochemical activity for L-Tyrosine, attributed to the increased surface area and electrocatalytic properties provided by the modifier. The electrode modifier was characterized using XRD and SEM–EDS techniques. Cyclic voltammetry (CV) and square wave voltammetry (SWV) were employed to investigate LTRS detection. Optimal LTRS oxidation occurred for the pH of 5.0, and the reaction was identified as irreversible and diffusion-controlled. This method enables the highly sensitive electrochemical detection of LTRS. Under optimized experimental conditions, the oxidation peak current of LTRS was directly proportional to its concentration in the range of 1.0–10&#xa0;µM, with a detection limit (LOD) of 20.07&#xa0;nM. The method was successfully applied to measure LTRS in pharmaceutical products, demonstrating satisfactory recovery, stability, and sensitivity. A probable electro-oxidation mechanism was proposed. These results indicate that the developed sensor could be valuable for pharmacokinetic studies and quality control laboratories.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Synergistic enhancement in voltammetric detection of L-Tyrosine using a glassy carbon electrode modified with the composite of graphene oxide, graphitic carbon nitride, and zinc oxide

  • 期刊论文

  • 发表日期：

    2025年9月18日

查看全文
  • Sandeep R. Kurundawade,
  • Sharanappa T. Nandibewoor

摘要

A novel and sensitive electrochemical sensor was developed for the detection of L-Tyrosine (LTRS), utilizing a composite of Graphene Oxide, Graphitic Carbon Nitride, and Zinc Oxide to functionalize a Glassy Carbon Electrode (GCE). The modified GCE exhibited significantly enhanced electrochemical activity for L-Tyrosine, attributed to the increased surface area and electrocatalytic properties provided by the modifier. The electrode modifier was characterized using XRD and SEM–EDS techniques. Cyclic voltammetry (CV) and square wave voltammetry (SWV) were employed to investigate LTRS detection. Optimal LTRS oxidation occurred for the pH of 5.0, and the reaction was identified as irreversible and diffusion-controlled. This method enables the highly sensitive electrochemical detection of LTRS. Under optimized experimental conditions, the oxidation peak current of LTRS was directly proportional to its concentration in the range of 1.0–10 µM, with a detection limit (LOD) of 20.07 nM. The method was successfully applied to measure LTRS in pharmaceutical products, demonstrating satisfactory recovery, stability, and sensitivity. A probable electro-oxidation mechanism was proposed. These results indicate that the developed sensor could be valuable for pharmacokinetic studies and quality control laboratories.