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<p>In this manuscript, we report a novel cytotoxic Ru (II) macrocyclic complex i.e., [C<sub>18</sub>H<sub>24</sub>N<sub>3</sub>O<sub>3</sub>RuCl<sub>2</sub>]Cl<sub>2</sub>, synthesized via template condensation reaction of 5-chloroisatin with 1,13-diamino-4,7,10-trioxatridacane in the presence of RuCl<sub>3</sub>.xH<sub>2</sub>O metal salt as template, under an ethanolic medium with a 1:1:1 molar ratios. The structural scaffolding of the complex has been confirmed by elemental analysis, NMR, UV, IR, mass spectrometry, and X-ray diffraction. In accordance with these spectral studies and XRD, an octahedral geometry has been proposed for the complex with 5.89&#xa0;nm and 1.11&#xa0;nm average crystalline size as calculated by Debye–Scherrer and Williamson–Hall plot methods respectively. Furthermore, the metal complex has been screened for antifungal and antibacterial activities. Biological evaluations revealed significant antimicrobial activity against Gram-negative <i>Escherichia coli</i> and Gram-positive <i>Staphylococcus aureus</i> bacterial strains, as well as fungal pathogens <i>Aspergillus niger</i> and <i>Penicillium chrysogenum</i>. The anticancer potential of the synthesized complex has also been analysed against MCF-7 (Human breast adenocarcinoma) cell lines using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT) and the result revealed the noteworthy potential of the complex as cytotoxic agent. These findings underscore the potential of this ruthenium (II) complex as a dual-action antimicrobial and anticancer agent, warranting further investigation for therapeutic applications.</p>

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Design, synthesis and characterization of novel ruthenium (II)-based macrocyclic complex with remarkable cytotoxic and antimicrobial potential

  • 期刊论文

  • 发表日期：

    2025年8月17日

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  • Urmila Phageria,
  • Krishna Atal,
  • Sushama Kumari,
  • Swati Bugalia

摘要

In this manuscript, we report a novel cytotoxic Ru (II) macrocyclic complex i.e., [C18H24N3O3RuCl2]Cl2, synthesized via template condensation reaction of 5-chloroisatin with 1,13-diamino-4,7,10-trioxatridacane in the presence of RuCl3.xH2O metal salt as template, under an ethanolic medium with a 1:1:1 molar ratios. The structural scaffolding of the complex has been confirmed by elemental analysis, NMR, UV, IR, mass spectrometry, and X-ray diffraction. In accordance with these spectral studies and XRD, an octahedral geometry has been proposed for the complex with 5.89 nm and 1.11 nm average crystalline size as calculated by Debye–Scherrer and Williamson–Hall plot methods respectively. Furthermore, the metal complex has been screened for antifungal and antibacterial activities. Biological evaluations revealed significant antimicrobial activity against Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus bacterial strains, as well as fungal pathogens Aspergillus niger and Penicillium chrysogenum. The anticancer potential of the synthesized complex has also been analysed against MCF-7 (Human breast adenocarcinoma) cell lines using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT) and the result revealed the noteworthy potential of the complex as cytotoxic agent. These findings underscore the potential of this ruthenium (II) complex as a dual-action antimicrobial and anticancer agent, warranting further investigation for therapeutic applications.