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<p>Determination of pharmaceutical compounds and biological species in real samples is of significant importance and has been widely considered in recent years. In this work, a voltammetric sensor has been designed for detecting epinephrine (EP). This sensor utilizes a bimetallic yttrium-zinc metal–organic framework (Y-Zn-MOF) to modify a carbon paste electrode (Y-Zn-MOFs/CPE), aiming to enhance the charge transfer rate. The electrocatalytic performance of the Y-Zn-MOFs/CPE sensor was analyzed using cyclic voltammetry, revealing improved performance compared to the unmodified electrode. The Y-Zn-MOFs significantly enhance the electrocatalytic activity toward EP. The Y-Zn-MOFs/CPE sensor exhibited a wide linear dynamic range from 0.01 to 700.0&#xa0;µM, with low limit of detection of 0.003&#xa0;µM for EP. Moreover, differential pulse voltammetry results indicated that the peak-to-peak separation for EP and acetaminophen (AC) was 170&#xa0;mV at the Y-Zn-MOFs/CPE. This suggests that the proposed electrode can simultaneously and selectively detect both compounds. It can also be utilized for detecting EP and AC in real specimens, achieving a recovery of 96.7–103.3%. This demonstrates a promising application potential for the electrochemical detection of EP and AC detection. </p>

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A bimetallic yttrium-zinc-based metal−organic framework as an efficient platform for voltammetric sensing epinephrine in the presence of acetaminophen

  • 期刊论文

  • 发表日期：

    2025年6月12日

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  • Shamsi Esmaeelzadeh,
  • Niloufar Akbarzadeh-T,
  • Somayeh Tajik,
  • Hadi Beitollahi

摘要

Determination of pharmaceutical compounds and biological species in real samples is of significant importance and has been widely considered in recent years. In this work, a voltammetric sensor has been designed for detecting epinephrine (EP). This sensor utilizes a bimetallic yttrium-zinc metal–organic framework (Y-Zn-MOF) to modify a carbon paste electrode (Y-Zn-MOFs/CPE), aiming to enhance the charge transfer rate. The electrocatalytic performance of the Y-Zn-MOFs/CPE sensor was analyzed using cyclic voltammetry, revealing improved performance compared to the unmodified electrode. The Y-Zn-MOFs significantly enhance the electrocatalytic activity toward EP. The Y-Zn-MOFs/CPE sensor exhibited a wide linear dynamic range from 0.01 to 700.0 µM, with low limit of detection of 0.003 µM for EP. Moreover, differential pulse voltammetry results indicated that the peak-to-peak separation for EP and acetaminophen (AC) was 170 mV at the Y-Zn-MOFs/CPE. This suggests that the proposed electrode can simultaneously and selectively detect both compounds. It can also be utilized for detecting EP and AC in real specimens, achieving a recovery of 96.7–103.3%. This demonstrates a promising application potential for the electrochemical detection of EP and AC detection.