<p>This study investigates the potential of aronia (rich in cyanidins) and turmeric (containing curcumin) extracts as natural indicators for acid–base titrations. The extracts were characterized using HPLC/DAD/ESI-MS^<i>n</i>. For the first time, this study explores the use of natural indicators in the titrations of polyprotic acids and bases. Aronia extract exhibited a color change from pink (acidic) to turquoise (basic), with absorption maxima at 515 and 610&#xa0;nm, respectively. It was effective for titrations involving weak bases with strong acids and polyprotic acids and bases, with relative errors around 0.5%. It was especially effective for determining the second end point in Na₂CO₃ titrations and the first end point in H₃PO₄ titrations, with relative errors around 1%. Turmeric extract demonstrated a yellow-to-orange color transition, with absorption maxima at 425 (acidic) and 460&#xa0;nm (basic). It was effective for titrations of weak acids with strong bases and the first end point in Na₂CO₃ titrations, with errors under 1%. Turmeric was also suitable for the second end point in H₃PO₄ titrations, with a relative error around 2%. Both natural indicators showed promising results compared to synthetic indicators. Aronia extract can be used in acid–base titrations instead of methyl red, while turmeric extract can replace phenolphthalein.</p> Graphical Abstract <p></p>