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<p>In this study, an oral pH-responsive carrier, carboxymethyl cellulose/hydroxyapatite/Fe<sub>3</sub>O<sub>4</sub> bio-nanocomposite hydrogel beads (CMC/HAp/Fe<sub>3</sub>O<sub>4</sub>), was prepared to control the release profile of anticancer doxorubicin (DOX) drug. Surface morphology of the CMC/HAp/Fe<sub>3</sub>O<sub>4</sub> bio-nanocomposite hydrogel beads was studied using different techniques. The magnetic measurement studies revealed a good superparamagnetic behavior for the prepared bio-nanocomposite hydrogel beads with a saturation magnetization of 28.73&#xa0;emu/g. The pH-responsive drug release was verified by <i>in vitro</i> release test and showed a lower release at acidic media (pH 1.2) and a higher release under alkaline conditions (i.e., pH 7.4 and 6.8). Besides, the MTT assay revealed that the DOX-loaded CMC/HAp/Fe<sub>3</sub>O<sub>4</sub> has the desired cytotoxicity against SW480 cells. According to the results, the prepared bio-nanocomposite hydrogel beads have a high potential for being used as biomaterials.</p>

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Carboxymethyl cellulose/hydroxyapatite/Fe3O4 bio-nanocomposite hydrogel beads: an efficient oral pH-responsive carrier for doxorubicin delivery

  • 期刊论文

  • 发表日期：

    2025年2月17日

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  • Rauf Foroutan,
  • Ali Mohammadzadeh,
  • Reza Mohammadi,
  • Siamak Javanbakht

摘要

In this study, an oral pH-responsive carrier, carboxymethyl cellulose/hydroxyapatite/Fe3O4 bio-nanocomposite hydrogel beads (CMC/HAp/Fe3O4), was prepared to control the release profile of anticancer doxorubicin (DOX) drug. Surface morphology of the CMC/HAp/Fe3O4 bio-nanocomposite hydrogel beads was studied using different techniques. The magnetic measurement studies revealed a good superparamagnetic behavior for the prepared bio-nanocomposite hydrogel beads with a saturation magnetization of 28.73 emu/g. The pH-responsive drug release was verified by in vitro release test and showed a lower release at acidic media (pH 1.2) and a higher release under alkaline conditions (i.e., pH 7.4 and 6.8). Besides, the MTT assay revealed that the DOX-loaded CMC/HAp/Fe3O4 has the desired cytotoxicity against SW480 cells. According to the results, the prepared bio-nanocomposite hydrogel beads have a high potential for being used as biomaterials.