<p>The droplet-based microfluidics technology achieves precise control over the behavior of droplets by designing the microchannel, controlling the flow, and managing the interactions of liquids. In this study, three-dimensional (<i>3D</i>) numerical simulations were conducted to investigate the behavior of droplets in a hydrophilic microchannel. With a hydrophilic microchannel, both wetting characteristics and microchannel geometry play a significant role in influencing the motion and behavior of droplets. The research introduces various droplet behavior regimes influenced by the contact angle (<i>θ</i>), capillary number (<i>Ca</i>), and viscosity ratio (<i>λ</i>), demonstrating that the influence of the hydrophilic microchannel occurs only at low capillary numbers. A predictive model for the critical capillary number to transition between contact and non-contact behaviors with the microchannel surface is proposed, described as follows: <InlineEquation ID="IEq1"> <InlineMediaObject> <ImageObject Color="BlackWhite" FileRef="11696_2025_3928_Article_IEq1.gif" Format="GIF" Height="19" Rendition="HTML" Resolution="72" Type="Linedraw" Width="160" /> </InlineMediaObject> <EquationSource Format="TEX">\(Ca&gt;f\left(\lambda \right)({a}_{1}C+{a}_{2})\)</EquationSource> <EquationSource Format="MATHML"><math> <mrow> <mi>C</mi> <mi>a</mi> <mo>&gt;</mo> <mi>f</mi> <mfenced close=")" open="("> <mi>λ</mi> </mfenced> <mrow> <mo stretchy="false">(</mo> <msub> <mi>a</mi> <mn>1</mn> </msub> <mi>C</mi> <mo>+</mo> <msub> <mi>a</mi> <mn>2</mn> </msub> <mo stretchy="false">)</mo> </mrow> </mrow> </math></EquationSource> </InlineEquation>. This research provides valuable insights for liquid-phase system analysis devices that can analyze and manipulate fluids in a hydrophilic microchannel.</p>