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<p>The bioactive potential of Jeju-Baek-Seohyang (JBS), scientifically known as <i>Daphne jejudoensis</i> M. Kim, was extensively investigated. The antioxidant activity of JBS was relatively lower compared to ascorbic acid in the DPPH and ABTS<sup>+</sup> assays. Despite this, JBS exhibited significant anti-inflammatory effects in lipopolysaccharide-stimulated RAW 264.7 cells showing an IC<sub>50</sub> value of 187.0&#xa0;µg&#xa0;mL<sup>−1</sup>, which was relatively lower than that of the <i>Centella asiatica</i> sample (77.0&#xa0;µg&#xa0;mL<sup>−1</sup>). Furthermore, the JBS sample evaluated in the cytotoxicity assay showed more than 100% RAW 264.7 cell viability even at 250&#xa0;ppm, a higher concentration than the <i>C. asiatica</i> sample. To characterize the phytochemicals responsible for these bioactivities, LC-ESI/MS and HPLC analyses were employed wherein daphnetin 7-<i>O</i>-glucoside (57.5&#xa0;mg&#xa0;g<sup>−1</sup>) and daphnetin (6.5&#xa0;mg&#xa0;g<sup>−1</sup>) were identified as the primary flavonoids in the extracts. This study contributes to the evaluation of the potential of JBS, a recently reclassified species that remains understudied, as a valuable medicinal and industrial substance. Further studies are proposed to fully characterize the medicinal properties of this plant.</p>

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Phytochemical characterization and bioactive potential of Daphne jejudoensis

  • 期刊论文

  • 发表日期：

    2025年1月21日

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  • Chang-Dae Lee,
  • Hyeonjun Yu,
  • Neil Patrick Uy,
  • Hwanhee Yu,
  • Chang-Ha Lee,
  • Hoon Kim,
  • Sanghyun Lee

摘要

The bioactive potential of Jeju-Baek-Seohyang (JBS), scientifically known as Daphne jejudoensis M. Kim, was extensively investigated. The antioxidant activity of JBS was relatively lower compared to ascorbic acid in the DPPH and ABTS+ assays. Despite this, JBS exhibited significant anti-inflammatory effects in lipopolysaccharide-stimulated RAW 264.7 cells showing an IC50 value of 187.0 µg mL−1, which was relatively lower than that of the Centella asiatica sample (77.0 µg mL−1). Furthermore, the JBS sample evaluated in the cytotoxicity assay showed more than 100% RAW 264.7 cell viability even at 250 ppm, a higher concentration than the C. asiatica sample. To characterize the phytochemicals responsible for these bioactivities, LC-ESI/MS and HPLC analyses were employed wherein daphnetin 7-O-glucoside (57.5 mg g−1) and daphnetin (6.5 mg g−1) were identified as the primary flavonoids in the extracts. This study contributes to the evaluation of the potential of JBS, a recently reclassified species that remains understudied, as a valuable medicinal and industrial substance. Further studies are proposed to fully characterize the medicinal properties of this plant.