Synthesis, characterization, antimicrobial activity of 2-amino-5-picoline and dipicolinic acid of Ni(II) and Cu(II) metal complexes

Ni(II) {(2a5p)₂[Ni(OH₂)₆][Ni(dipic)₂]₂.2H₂O, 1} and Cu(II) {[Cu(dipic)(2a5p)(H₂O)].H₂O, 2} complexes obtained from 2-amino-5-picoline (2a5p) with dipicolinic acid (H₂dipic) and Cu(II) complex {[(H₂O)(dipic)Cu(OH)Cu(OH)(H₂O)₂Cu(dipic)(H₂O)].2H₂O, 3} of H₂dipic have been synthesized and characterized by atomic absorption spectroscopy (AAS), ultraviolet–visible region (UV–Vis), Fourier transform infrared spectroscopy (FT-IR), conductivity measurement, magnetic measurement and X-ray crystallography. Furthermore, antimicrobial properties of starting and syntheses complexes have also been tested against C. krusei (ATCC 6258), C. albicans (ATCC 14053) and C. parapsilosis (ATCC 22019) (yeast) for antifungal activity and E. faecalis (ATCC 29212), E. coli (ATCC 25922) and S. aureus (ATCC 29213) for antibacterial activity. The antimicrobial activities of results were compared to those of standard agents such as fluconazole, levofloxacin, cefepime and vancomycin.