Palladium-catalyzed C(sp3)-C(sp2) coupling: synthesis of C(3)-arylphthalides
摘要
We have achieved an efficient synthesis of C(3)-arylphthalides by coupling C(3)-bromophthalides and arylboronic acids under palladium catalysis. The C(sp3)-C(sp2) coupling worked well in the presence of water to provide products in a high yield.
Graphical Abstract