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Background <p>Obesity is an independent risk factor for various chronic diseases and malignancies. The incidence of thyroid cancer is significantly higher in obese populations. Current clinical practice often adopts staged treatment for obesity with thyroid cancer, which presents challenges including cancer management and prolonged recovery. The simultaneous implementation of bariatric surgery and radical thyroidectomy may represent a more efficient therapeutic strategy. This study evaluates the clinical value of this combined approach by comparing clinical data with standalone bariatric surgery, focusing on feasibility, safety, and comparative metabolic and weight loss efficacy.</p> Methods <p>Patients who underwent laparoscopic bariatric surgery at our center from March 2015 to March 2023 were retrospectively collected. Using propensity score matching method, patients were stratified into two cohorts: the simultaneous group (SS group, <i>n</i> = 24) receiving combined bariatric surgery with radical thyroidectomy, and bariatric surgery group (BS group, <i>n</i> = 72). Surgical outcomes, complications, and 2-year follow-up data were compared.</p> Results <p>Preoperative characteristics were comparable (<i>p</i> &gt; 0.05). The SS group had longer operative duration (median 242.50 vs. 104.50&#xa0;min, <i>p</i> &lt; 0.05) and higher blood loss (35.00 vs. 25.00 mL, <i>p</i> &lt; 0.05) than the BS group, with no significant difference in short-term complications (<i>p</i> &gt; 0.05). At 2 years postoperatively, the SS group reported no hypocalcemia, hypothyroidism, or cancer recurrence. Both groups achieved significant, comparable reductions in weight, body mass index, and metabolic parameters postoperatively.</p> Conclusions <p>For patients with obesity complicated by T1-T2N0M0 low-risk papillary thyroid carcinoma, this pilot study demonstrates that simultaneous bariatric surgery and radical thyroidectomy is safe and feasible, without an increased risk of complications. The efficacy of this combined approach in terms of weight loss and metabolic improvement is comparable to that of standalone bariatric surgery, highlighting its clinical application value in centers with relevant combined clinical experience.</p>

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Efficacy Analysis of Simultaneous Bariatric Surgery and Radical Thyroidectomy in Patients with Obesity and Low-Risk Papillary Thyroid Cancer: A Pilot Feasibility and Safety Study

  • 期刊论文

  • 发表日期：

    2026年5月23日

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  • Dehui Wang,
  • Zilong Wu,
  • Yan Liu,
  • Jie Li,
  • Bing Wu,
  • Ruixiang Hu,
  • Cunchuan Wang

摘要

Background

Obesity is an independent risk factor for various chronic diseases and malignancies. The incidence of thyroid cancer is significantly higher in obese populations. Current clinical practice often adopts staged treatment for obesity with thyroid cancer, which presents challenges including cancer management and prolonged recovery. The simultaneous implementation of bariatric surgery and radical thyroidectomy may represent a more efficient therapeutic strategy. This study evaluates the clinical value of this combined approach by comparing clinical data with standalone bariatric surgery, focusing on feasibility, safety, and comparative metabolic and weight loss efficacy.

Methods

Patients who underwent laparoscopic bariatric surgery at our center from March 2015 to March 2023 were retrospectively collected. Using propensity score matching method, patients were stratified into two cohorts: the simultaneous group (SS group, n = 24) receiving combined bariatric surgery with radical thyroidectomy, and bariatric surgery group (BS group, n = 72). Surgical outcomes, complications, and 2-year follow-up data were compared.

Results

Preoperative characteristics were comparable (p > 0.05). The SS group had longer operative duration (median 242.50 vs. 104.50 min, p < 0.05) and higher blood loss (35.00 vs. 25.00 mL, p < 0.05) than the BS group, with no significant difference in short-term complications (p > 0.05). At 2 years postoperatively, the SS group reported no hypocalcemia, hypothyroidism, or cancer recurrence. Both groups achieved significant, comparable reductions in weight, body mass index, and metabolic parameters postoperatively.

Conclusions

For patients with obesity complicated by T1-T2N0M0 low-risk papillary thyroid carcinoma, this pilot study demonstrates that simultaneous bariatric surgery and radical thyroidectomy is safe and feasible, without an increased risk of complications. The efficacy of this combined approach in terms of weight loss and metabolic improvement is comparable to that of standalone bariatric surgery, highlighting its clinical application value in centers with relevant combined clinical experience.