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Abstract <p>Portomesenteric vein thrombosis (PMVT) is a rare but potentially fatal complication of metabolic and bariatric surgery (MBS). This study aimed to describe the clinical presentation, management, and outcomes of PMVT in a large, international cohort of patients undergoing MBS. As a case-series without denominators, this study provides descriptive epidemiology rather than incidence estimates.</p> <p>In this cohort, higher BMI (OR 1.21) and diabetes mellitus (OR 12.06) were associated with increased mortality in an exploratory multivariable analysis; however, due to the small number of events (<i>n</i> = 11), these findings should be considered exploratory and hypothesis-generating. Abdominal pain was the most frequent symptom (87%). The superior mesenteric vein was the most affected vessel (68.8%). The overall mortality rate was 14.3%.</p> Conclusion <p>PMVT after MBS is a serious complication with significant mortality. A high index of suspicion is required for early diagnosis and management. In this cohort, higher BMI and diabetes mellitus were associated with mortality; however, these findings should be considered exploratory due to the small number of events. Further research is needed to optimize thromboprophylaxis protocols in high-risk patients.</p>

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Portomesenteric Vein Thrombosis after Metabolic and Bariatric Surgery: a Multi-Centric International Study

  • 期刊论文

  • 发表日期：

    2026年4月10日

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  • Ala Wafa,
  • Shahab Shahabi Shahmiri,
  • Mohammad Mahjoubi,
  • Mohamed Hany,
  • Hazem Almomani,
  • Osama Taha,
  • Ahmed Abokhozima,
  • Abd-Elfattah Kalmoush,
  • Seyed Morteza Mousavi Naeini,
  • Shima Rezaei Bana,
  • Amir Hossein Davarpanah Jazi,
  • Mohammad Kermansaravi

摘要

Abstract

Portomesenteric vein thrombosis (PMVT) is a rare but potentially fatal complication of metabolic and bariatric surgery (MBS). This study aimed to describe the clinical presentation, management, and outcomes of PMVT in a large, international cohort of patients undergoing MBS. As a case-series without denominators, this study provides descriptive epidemiology rather than incidence estimates.

In this cohort, higher BMI (OR 1.21) and diabetes mellitus (OR 12.06) were associated with increased mortality in an exploratory multivariable analysis; however, due to the small number of events (n = 11), these findings should be considered exploratory and hypothesis-generating. Abdominal pain was the most frequent symptom (87%). The superior mesenteric vein was the most affected vessel (68.8%). The overall mortality rate was 14.3%.

Conclusion

PMVT after MBS is a serious complication with significant mortality. A high index of suspicion is required for early diagnosis and management. In this cohort, higher BMI and diabetes mellitus were associated with mortality; however, these findings should be considered exploratory due to the small number of events. Further research is needed to optimize thromboprophylaxis protocols in high-risk patients.