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Background <p>Prospective studies examining the changes in resting energy expenditure, metabolic adaptation (MA), and body composition following sleeve gastrectomy (SG) are limited, especially among minority populations.</p> Methods <p>Data were included from a secondary analysis of participants (<i>n</i> = 24; mean ± SD: 42 ± 11 y, 62.5% Female, 58.3% Hispanic, 20.8% non-Hispanic White, 37.5% with type 2 diabetes not on insulin, BMI, 41.9 ± 4.7&#xa0;kg/m<sup>2</sup>) undergoing SG from a 24-month prospective study. REE was measured using indirect calorimetry at baseline, 1.5, and 6 months. Body composition (fat mass [FM] and fat-free mass [FFM]) was measured via bioelectrical impedance analysis at baseline, 1.5, 6, 12, and 24 months. Metabolic Adaptation (MA) was calculated by subtracting measured REE from predicted REE using a linear model that included FFM.</p> Results <p>REE significantly decreased from baseline to 1.5 months (-371.8&#xa0;kcal/day, 95%CI: -577.5 to -166.1, <i>p</i> = 0.0005) and 6 months (-374.2&#xa0;kcal/day, 95%CI: -647.3 to -101.0, <i>p</i> = 0.006), but was not significantly different from 1.5 to 6 months (<i>p</i> = 0.99). MA was − 328.8&#xa0;kcal/day (95%CI: -480.6 to -128.9, <i>p</i> = 0.008) and − 306.7&#xa0;kcal/day (95%CI: -553.9 to -59.4, <i>p</i> = 0.02) at 1.5 and 6 months, but was not significantly different from 1.5 to 6 months (<i>p</i> = 0.97). REE and MA at 1.5 and 6 months were not associated with FM or FFM at 12- and 24-months following SG.</p> Conclusion <p>The acute changes in REE and MA did not blunt weight loss and were not associated with body composition at 12 and 24 months; however, our findings should be interpreted with caution, given the small sample size and potential inaccuracies in body composition measurements. </p>

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Resting Energy Expenditure and Metabolic Adaptation Following Sleeve Gastrectomy in Hispanic Adults with Obesity

  • 期刊论文

  • 发表日期：

    2026年3月30日

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  • Collin J. Popp,
  • Boyan Zhou,
  • Sally M. Vanegas,
  • Migdalia Reid,
  • Manish S. Parikh,
  • Christine J. Ren-Fielding,
  • Melanie Jay,
  • José O. Alemán

摘要

Background

Prospective studies examining the changes in resting energy expenditure, metabolic adaptation (MA), and body composition following sleeve gastrectomy (SG) are limited, especially among minority populations.

Methods

Data were included from a secondary analysis of participants (n = 24; mean ± SD: 42 ± 11 y, 62.5% Female, 58.3% Hispanic, 20.8% non-Hispanic White, 37.5% with type 2 diabetes not on insulin, BMI, 41.9 ± 4.7 kg/m2) undergoing SG from a 24-month prospective study. REE was measured using indirect calorimetry at baseline, 1.5, and 6 months. Body composition (fat mass [FM] and fat-free mass [FFM]) was measured via bioelectrical impedance analysis at baseline, 1.5, 6, 12, and 24 months. Metabolic Adaptation (MA) was calculated by subtracting measured REE from predicted REE using a linear model that included FFM.

Results

REE significantly decreased from baseline to 1.5 months (-371.8 kcal/day, 95%CI: -577.5 to -166.1, p = 0.0005) and 6 months (-374.2 kcal/day, 95%CI: -647.3 to -101.0, p = 0.006), but was not significantly different from 1.5 to 6 months (p = 0.99). MA was − 328.8 kcal/day (95%CI: -480.6 to -128.9, p = 0.008) and − 306.7 kcal/day (95%CI: -553.9 to -59.4, p = 0.02) at 1.5 and 6 months, but was not significantly different from 1.5 to 6 months (p = 0.97). REE and MA at 1.5 and 6 months were not associated with FM or FFM at 12- and 24-months following SG.

Conclusion

The acute changes in REE and MA did not blunt weight loss and were not associated with body composition at 12 and 24 months; however, our findings should be interpreted with caution, given the small sample size and potential inaccuracies in body composition measurements.