Scholarlink

<p>Obesity is associated with hyperuricemia through visceral adiposity, inflammation, and impaired renal urate handling. We systematically reviewed PubMed, Embase, Scopus, and Web of Science (January 2025) and meta-analyzed longitudinal changes in serum uric acid (SUA) after metabolic and bariatric surgery (MBS) and associations with creatinine (Cr), blood urea nitrogen (BUN), and waist circumference (WC). Forty-two studies (<i>n</i> = 9,468) were included and assessed using the Newcastle–Ottawa Scale. SUA showed a transient, non-significant rise at 7&#xa0;days, then declined progressively, with the greatest reduction at 12&#xa0;months (MD − 1.43&#xa0;mg/dL; 95% CI − 1.80 to − 1.07). Reductions were larger after Roux-en-Y gastric bypass than sleeve gastrectomy. Meta-regression showed positive associations of postoperative SUA with Cr, WC, and BMI, but not BUN. MBS is associated with sustained urate reduction linked to renal and visceral adiposity improvements.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Effects of Metabolic and Bariatric Surgery on Serum Uric Acid and its Association with Renal Function, and Visceral Adiposity: A Systematic Review and Meta-Analysis

  • 期刊论文

  • 发表日期：

    2026年3月17日

查看全文
  • Delaram Moosavi,
  • Seyed Mohammad Mehdi Khadem,
  • Nogol Motamed-Gorji,
  • Seyed Arash Javadmoosavi,
  • Shahab Shahabi

摘要

Obesity is associated with hyperuricemia through visceral adiposity, inflammation, and impaired renal urate handling. We systematically reviewed PubMed, Embase, Scopus, and Web of Science (January 2025) and meta-analyzed longitudinal changes in serum uric acid (SUA) after metabolic and bariatric surgery (MBS) and associations with creatinine (Cr), blood urea nitrogen (BUN), and waist circumference (WC). Forty-two studies (n = 9,468) were included and assessed using the Newcastle–Ottawa Scale. SUA showed a transient, non-significant rise at 7 days, then declined progressively, with the greatest reduction at 12 months (MD − 1.43 mg/dL; 95% CI − 1.80 to − 1.07). Reductions were larger after Roux-en-Y gastric bypass than sleeve gastrectomy. Meta-regression showed positive associations of postoperative SUA with Cr, WC, and BMI, but not BUN. MBS is associated with sustained urate reduction linked to renal and visceral adiposity improvements.