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Methods <p>We quantified the expression levels of four miRNAs (hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-223-3p, and hsa-let-7a) in liver samples obtained during bariatric metabolic surgery from patients with obesity and healthy controls using qPCR. Expression was normalized to hsa-miR-24-3p, selected as the most stable reference gene in our cohort. Associations between miRNA levels and clinical or demographic variables (sex, AMPs) were also explored.</p> Results <p>Compared with controls, patients with obesity showed significant dysregulation of hsa-miR-128-3p and hsa-miR-223-3p, independent of histological liver alterations. No consistent changes were observed for hsa-miR-21-3p or hsa-let-7a. Clinical variables, including AMPs, did not account for the observed differences. </p> Conclusion <p>miR-128-3p and miR-223-3p are linked to obesity-related metabolic dysfunction and emerge as promising biomarkers or therapeutic targets.</p> Graphical Abstract <p></p>

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miR-128-3p and miR-223-3p as Potential Biomarkers of Metabolic Dysfunction in Liver Tissue from Patients Undergoing Metabolic Bariatric Surgery

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月12日

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  • Raquel Rodríguez,
  • Daniel Salete-Granado,
  • Lourdes Hernández-Cosido,
  • María Teresa Cabero Morán,
  • Oscar Blanco,
  • Nuria Matesanz,
  • Vanessa Rueda-Cala,
  • Fabiola Campo,
  • María-Ángeles Pérez-Nieto,
  • Carlos Gutiérrez Cerrajero,
  • Edgar Bernardo,
  • Ronald Macías,
  • Guadalupe Sabio,
  • Jorge-Luis Torres,
  • Maura Rojas-Pirela,
  • Miguel Marcos

摘要

Methods

We quantified the expression levels of four miRNAs (hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-223-3p, and hsa-let-7a) in liver samples obtained during bariatric metabolic surgery from patients with obesity and healthy controls using qPCR. Expression was normalized to hsa-miR-24-3p, selected as the most stable reference gene in our cohort. Associations between miRNA levels and clinical or demographic variables (sex, AMPs) were also explored.

Results

Compared with controls, patients with obesity showed significant dysregulation of hsa-miR-128-3p and hsa-miR-223-3p, independent of histological liver alterations. No consistent changes were observed for hsa-miR-21-3p or hsa-let-7a. Clinical variables, including AMPs, did not account for the observed differences.

Conclusion

miR-128-3p and miR-223-3p are linked to obesity-related metabolic dysfunction and emerge as promising biomarkers or therapeutic targets.

Graphical Abstract