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Background <p>Compared to Roux-en-Y gastric bypass, cases of dumping syndrome (DS) occur significantly less frequently after one anastomosis gastric bypass due to the longer gastric pouch. Recent studies have proposed supplementation of gastric bypass with modified fundoplication using the excluded part of the stomach; however, only a few cases have been reported, as this is often performed in revision surgeries.</p> <p>This study aimed to compare the incidence of early and late DS after “FundoRingOAGB” and standard one anastomosis gastric bypass by assessing the OGTT, insulin levels, and Sigstad scores as outcome measures.</p> Materials and Methods <p>This was a single-center, prospective, interventional, open-label (no masking) RCT (FundoRing Trial) with a 1-year follow-up period. The endpoints were oral glucose tolerance tests (OGTT), insulin levels, Sigstad scores, early and late DS symptoms.</p> Results <p>Overall,1000 patients (n=500 FundoRing One-anastomosis gastric bypass [f-OAGB] vs. n=500 standard OAGB [s-OAGB]) with complete follow-up data were included in the study. No leaks, bleeding, or mortality occurred in either group. At 1-year, BMI in the f-OAGB group was 27.0 ± 0.75 vs. 29.0 ± 0.66 s-OAGB group (p=0.04). DS symptoms were observed in 98 (19.6%) and 175 (35%) patients in the f-OAGB and s-OAGB groups, respectively (P =0.001). Sigstad’s scores for the f-OAGB and s-OAGB groups were 2.8 ± 0.9 and 5.1 ± 1.3, respectively (p=0.001).</p> Conclusion <p>Modified fundoplication of the OAGB-excluded stomach significantly decreased early and late DS symptoms more effectively than standard OAGB at 1 year.</p>

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Comparison of Dumping Syndrome After FundoRing and Standard One-anastomosis Gastric Bypass: A Randomized Controlled Trial

  • 期刊论文

  • 发表日期：

    2025年12月4日

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  • Oral Ospanov,
  • Laura Danyarova,
  • Kassymkhan Sultanov,
  • Galymjan Duysenov,
  • Nurlan Zharov,
  • Bakhtiyar Yelembayev,
  • Shakhizada Ospanova

摘要

Background

Compared to Roux-en-Y gastric bypass, cases of dumping syndrome (DS) occur significantly less frequently after one anastomosis gastric bypass due to the longer gastric pouch. Recent studies have proposed supplementation of gastric bypass with modified fundoplication using the excluded part of the stomach; however, only a few cases have been reported, as this is often performed in revision surgeries.

This study aimed to compare the incidence of early and late DS after “FundoRingOAGB” and standard one anastomosis gastric bypass by assessing the OGTT, insulin levels, and Sigstad scores as outcome measures.

Materials and Methods

This was a single-center, prospective, interventional, open-label (no masking) RCT (FundoRing Trial) with a 1-year follow-up period. The endpoints were oral glucose tolerance tests (OGTT), insulin levels, Sigstad scores, early and late DS symptoms.

Results

Overall,1000 patients (n=500 FundoRing One-anastomosis gastric bypass [f-OAGB] vs. n=500 standard OAGB [s-OAGB]) with complete follow-up data were included in the study. No leaks, bleeding, or mortality occurred in either group. At 1-year, BMI in the f-OAGB group was 27.0 ± 0.75 vs. 29.0 ± 0.66 s-OAGB group (p=0.04). DS symptoms were observed in 98 (19.6%) and 175 (35%) patients in the f-OAGB and s-OAGB groups, respectively (P =0.001). Sigstad’s scores for the f-OAGB and s-OAGB groups were 2.8 ± 0.9 and 5.1 ± 1.3, respectively (p=0.001).

Conclusion

Modified fundoplication of the OAGB-excluded stomach significantly decreased early and late DS symptoms more effectively than standard OAGB at 1 year.