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Introduction <p>The optimal biliopancreatic limb (BPL) length in One Anastomosis Gastric Bypass (OAGB) remains debated, largely due to limited long-term outcome data. The primary objective of this study was to evaluate five-year results of weight loss, metabolic outcomes, and complication rates following OAGB with a fixed 150&#xa0;cm BPL.</p> Methods <p>This retrospective study was conducted at a high-volume bariatric center within the National Health Service (NHS) in the United Kingdom. We reviewed patients who underwent OAGB with a fixed 150&#xa0;cm BPL between December 2015 and June 2019. Perioperative care followed the standard bariatric protocol of our institution. Patients were followed at six-month intervals for two years, and again at five years post-operatively.</p> Results <p>274 patients were included, with a five-year follow-up rate of 73.7%. At two years, Mean %Excess Weight Loss (%EWL) was 77.0% (95% CI: 73.5–80.5) and Mean %Total Weight Loss (%TWL) was 35.0% (95% CI: 33.5–36.5). At five years, mean %EWL was 64.1% (95% CI: 60.7–67.5) and %TWL was 29.4% (95% CI: 27.9–30.9). Remission rates for type 2 diabetes, hypertension, and dyslipidemia were 55.8%, 32.2%, and 22.7%, respectively. The marginal ulcer rate was 4.5% (<i>n</i> = 9). Conversion to Roux-en-Y configuration (RYC) occurred in 5.9% (<i>n</i> = 12) of patients, and the malnutrition rate at five years was 0.5% (<i>n</i> = 1).</p> Conclusion <p>OAGB with a 150&#xa0;cm BPL demonstrated effective outcomes with acceptable complication rates and a favorable balance between efficacy and safety, with a low incidence of severe malnutrition.</p> Graphical Abstract <p></p>

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One Anastomosis Gastric Bypass with a 150 cm Biliopancreatic Limb: Five-Year Outcomes from a Retrospective Single-Centre Cohort

  • 期刊论文

  • 发表日期：

    2025年12月8日

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  • G Balamurugan,
  • Laurence Hunt,
  • Madeleine Walton,
  • Mayuri Vinod,
  • Maureen Boyle,
  • Kamal Mahawar

摘要

Introduction

The optimal biliopancreatic limb (BPL) length in One Anastomosis Gastric Bypass (OAGB) remains debated, largely due to limited long-term outcome data. The primary objective of this study was to evaluate five-year results of weight loss, metabolic outcomes, and complication rates following OAGB with a fixed 150 cm BPL.

Methods

This retrospective study was conducted at a high-volume bariatric center within the National Health Service (NHS) in the United Kingdom. We reviewed patients who underwent OAGB with a fixed 150 cm BPL between December 2015 and June 2019. Perioperative care followed the standard bariatric protocol of our institution. Patients were followed at six-month intervals for two years, and again at five years post-operatively.

Results

274 patients were included, with a five-year follow-up rate of 73.7%. At two years, Mean %Excess Weight Loss (%EWL) was 77.0% (95% CI: 73.5–80.5) and Mean %Total Weight Loss (%TWL) was 35.0% (95% CI: 33.5–36.5). At five years, mean %EWL was 64.1% (95% CI: 60.7–67.5) and %TWL was 29.4% (95% CI: 27.9–30.9). Remission rates for type 2 diabetes, hypertension, and dyslipidemia were 55.8%, 32.2%, and 22.7%, respectively. The marginal ulcer rate was 4.5% (n = 9). Conversion to Roux-en-Y configuration (RYC) occurred in 5.9% (n = 12) of patients, and the malnutrition rate at five years was 0.5% (n = 1).

Conclusion

OAGB with a 150 cm BPL demonstrated effective outcomes with acceptable complication rates and a favorable balance between efficacy and safety, with a low incidence of severe malnutrition.

Graphical Abstract