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Introduction <p>Although laparoscopic sleeve gastrectomy (LSG) effectively addresses obesity, its outcomes on hyperuricemia (HUA) remission remain inconsistent. We aimed to identify baseline predictors and develop a nomogram for HUA persistence six months following LSG.</p> Methods <p>We retrospectively analyzed patients with obesity and HUA undergoing primary LSG at Huashan Hospital. An independent validation cohort from the Affiliated Hospital of Xuzhou Medical University was included. Clinical data, including demographics, anthropometric measurements, and biochemical markers were analyzed. Logistic regression analyses identified independent predictors of persistent HUA, and a predictive nomogram was developed and externally validated.</p> Results <p>A total of 631 patients was enrolled in this study. Persistent HUA was observed in 41.8% (159/380) of patients in the training cohort. Multivariate analysis identified male sex (OR = 4.97, 95% CI: 2.35–10.51, <i>P</i> &lt; 0.001), waist circumference (WC; OR = 1.06, 95% CI: 1.02–1.10, <i>P</i> = 0.006), and baseline UA levels (OR = 1.01, 95% CI: 1.01–1.02, <i>P</i> &lt; 0.001) as significant predictors. The nomogram demonstrated excellent discriminative ability (AUC = 0.85, 95% CI: 0.82–0.86) and calibration. In the validation cohort, persistent HUA was observed in 35.5% (89/251), and the nomogram maintained robust predictive performance (AUC = 0.81, 95% CI: 0.76–0.82).</p> Conclusion <p>Male sex, increased WC, and elevated baseline UA predict postoperative persistent HUA. The nomogram provides a practical clinical tool for predicting short-term HUA non-remission post-LSG.</p>

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Baseline Risk Factors and Predictive Nomogram for Short-Term Persistent Hyperuricemia Following Laparoscopic Sleeve Gastrectomy: A Dual Center Study

  • 期刊论文

  • 发表日期：

    2025年10月31日

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  • Yuxiao Chu,
  • Jian Wang,
  • Chong Cao,
  • Qiyuan Yao,
  • Yian Zhao,
  • Qiwei Shen,
  • Bo Xu,
  • Jian Hong,
  • Xiaojian Fu,
  • Xiaocheng Zhu,
  • Yikai Shao,
  • Libin Yao,
  • Rong Hua

摘要

Introduction

Although laparoscopic sleeve gastrectomy (LSG) effectively addresses obesity, its outcomes on hyperuricemia (HUA) remission remain inconsistent. We aimed to identify baseline predictors and develop a nomogram for HUA persistence six months following LSG.

Methods

We retrospectively analyzed patients with obesity and HUA undergoing primary LSG at Huashan Hospital. An independent validation cohort from the Affiliated Hospital of Xuzhou Medical University was included. Clinical data, including demographics, anthropometric measurements, and biochemical markers were analyzed. Logistic regression analyses identified independent predictors of persistent HUA, and a predictive nomogram was developed and externally validated.

Results

A total of 631 patients was enrolled in this study. Persistent HUA was observed in 41.8% (159/380) of patients in the training cohort. Multivariate analysis identified male sex (OR = 4.97, 95% CI: 2.35–10.51, P < 0.001), waist circumference (WC; OR = 1.06, 95% CI: 1.02–1.10, P = 0.006), and baseline UA levels (OR = 1.01, 95% CI: 1.01–1.02, P < 0.001) as significant predictors. The nomogram demonstrated excellent discriminative ability (AUC = 0.85, 95% CI: 0.82–0.86) and calibration. In the validation cohort, persistent HUA was observed in 35.5% (89/251), and the nomogram maintained robust predictive performance (AUC = 0.81, 95% CI: 0.76–0.82).

Conclusion

Male sex, increased WC, and elevated baseline UA predict postoperative persistent HUA. The nomogram provides a practical clinical tool for predicting short-term HUA non-remission post-LSG.